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dc.contributor.author이현주-
dc.date.accessioned2017-11-13T01:41:45Z-
dc.date.available2017-11-13T01:41:45Z-
dc.date.issued2016-01-
dc.identifier.citationPEDIATRIC RESEARCH, v. 79, NO 2, Page. 287-294en_US
dc.identifier.issn0031-3998-
dc.identifier.issn1530-0447-
dc.identifier.urihttps://www.nature.com/articles/pr2015224-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/30640-
dc.description.abstractBACKGROUND: Prenatal or postnatal systemic inflammation can contribute to the development of bronchopulmonary dysplasia (BPD). We investigated whether prenatal intra-amniotic (i.a.) inflammation or early postnatal systemic inflammation can induce BPD in a rat model. METHODS: One microgram of lipopolysaccharide (LPS) or vehicle was injected into the amniotic sacs 2 d before delivery (E20). After birth, 0.25 mg/kg of LPS or vehicle was injected into the peritoneum of pups on postnatal day (P)1, P3, and P5. On P7 and P14, peripheral blood (PB), bronchoalveolar lavage fluid (BALF), and lung tissue were obtained and analyzed. RESULTS: Postnatal i.p. injections of LPS significantly increased neutrophil counts in PB and BALF on P7 and P14. Similarly, pro inflammatory cytokine and angiogenic factor transcript levels were increased in the lung by i.p. LPS on P7. Alveolar and pulmonary vascular development was markedly disrupted by i.p. LPS on P14. However, pretreatment with i.a. LPS significantly negated the detrimental effects of postnatal i.p. LPS on PB and BALF neutrophil counts and on lung proinflammatory cytokine expression and histopathological changes. CONCLUSION: Exposure to early postnatal systemic LPS induces BPD, an arrest in alveolarization, in neonatal rats. Preceding exposure to i.a. LPS protects the lungs against BPD triggered by postnatal systemic inflammation.en_US
dc.description.sponsorshipThis study was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korean Government (MOE) (2010-0021644), the Seoul National University Bundang Hospital Research Fund (grant no. 02-2013-118), and a grant of the Korean Health Technology R&D Project funded by the Ministry of Health & Welfare, Republic of Korea (A112023).en_US
dc.language.isoenen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.subjectCHRONIC LUNG-DISEASEen_US
dc.subjectNF-KAPPA-Ben_US
dc.subjectPRETERM LAMBSen_US
dc.subjectFETAL SHEEPen_US
dc.subjectMECHANICAL VENTILATIONen_US
dc.subjectANIMAL-MODELSen_US
dc.subjectNEWBORN RATSen_US
dc.subjectONSET SEPSISen_US
dc.subjectENDOTOXINen_US
dc.subjectPULMONARYen_US
dc.titleProtective effect of chorioamnionitis on the development of bronchopulmonary dysplasia triggered by postnatal systemic inflammation in neonatal ratsen_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume79-
dc.identifier.doi10.1038/pr.2015.224-
dc.relation.page287-294-
dc.relation.journalPEDIATRIC RESEARCH-
dc.contributor.googleauthorChoi, Chang Won-
dc.contributor.googleauthorLee, Juyoung-
dc.contributor.googleauthorOh, Joo Youn-
dc.contributor.googleauthorLee, Seung Hyun-
dc.contributor.googleauthorLee, Hyun Ju-
dc.contributor.googleauthorKim, Beyong Il-
dc.relation.code2016002660-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidblesslee77-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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