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Low Serum Vitamin D Levels May Contribute to Gastric Dysmotility in de novo Parkinson's Disease

Title
Low Serum Vitamin D Levels May Contribute to Gastric Dysmotility in de novo Parkinson's Disease
Author
김희태
Keywords
25-Hydroxyvitamin D-3; Gastric emptying time; Parkinson's disease; Vitamin D
Issue Date
2016-01
Publisher
KARGER
Citation
NEURODEGENERATIVE DISEASES, v. 16, NO 3-4, Page. 199-205
Abstract
Background and Objectives: Gastrointestinal dysfunction is a common non motor symptom in Parkinson's disease (PD). However, the potential association between vitamin D and gastroparesis in PD has not been previously investigated. The aim of this study was to compare vitamin D levels between drug-naive de novo PD patients with normal gastric emptying and those with delayed gastric emptying. Methods: Fifty-one patients with drug-naive de novo PD and 20 age-matched healthy controls were enrolled in this study. Gastric emptying time (GET) was assessed by scintigraphy, and gastric emptying half-time (T-1/2) was determined. The PD patients were divided into a delayed-GET group and a normal-GET group. Results: The serum 25-hydroxyvitamin D-3 levels were decreased in the delayed-GET group compared with the normal-GET and control groups (11.59 +/- 4.90 vs. 19.43 +/- 6.91 and 32.69 +/- 4.93, respectively, p ˂ 0.01). In the multivariate model, the serum 25-hydroxyvitamin D-3 level was independently associated with delayed gastric emptying in PD patients. Conclusions: Vitamin D status may be an independent factor for gastric dysmotility in PD. Although the underlying mechanism remains to be characterized, vitamin D status may play a role in the pathogenesis of delayed gastric emptying in drug-naive PD. (C) 2016 S. Karger AG, Basel
URI
https://www.karger.com/Article/FullText/441917http://hdl.handle.net/20.500.11754/30600
ISSN
1660-2854; 1660-2862
DOI
10.1159/000441917
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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