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dc.contributor.author노재숙-
dc.date.accessioned2017-11-09T01:45:26Z-
dc.date.available2017-11-09T01:45:26Z-
dc.date.issued2016-01-
dc.identifier.citationJOURNAL OF MEDICINAL FOOD, v. 19, NO 1, Page. 73-84en_US
dc.identifier.issn1096-620X-
dc.identifier.issn1557-7600-
dc.identifier.urihttp://online.liebertpub.com/doi/10.1089/jmf.2015.3467-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/30592-
dc.description.abstractThis study investigated the dose- and time-dependent effects of caffeine consumption throughout puberty in peripubertal rats. A total of 85 male SD rats were randomly divided into four groups: control and caffeine-fed groups with 20, 60, or 120mg/kg/day through oral gavage for 10, 20, 30, or 40 days. Caffeine decreased body weight gain and food consumption in a dose- and time-dependent manner, accompanied by a reduction in muscle and body fat. In addition, it caused a shortening and lightening of leg bones and spinal column. The total height of the growth plate decreased sharply at 40 days in the controls, but not in the caffeine-fed groups, and the height of hypertrophic zone in the caffeine-fed groups was lower than in the control. Caffeine increased the height of the secondary spongiosa, whereas parameters related to bone formation, such as bone area ratio, thickness and number of trabeculae, and bone perimeter, were significantly reduced. Furthermore, serum levels of IGF-1, estradiol, and testosterone were also reduced by the dose of caffeine exposure. Our results demonstrate that caffeine consumption can dose- and time-dependently inhibit longitudinal bone growth in immature male rats, possibly by blocking the physiologic changes in body composition and hormones relevant to bone growth.en_US
dc.description.sponsorshipY.-Y.C. and Y.C. have contributed equally to this article. The authors would like to thank Mr. Taegeun Kim for his excellent technical assistance with DXA. This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2013R1A1A3006054, 2014 R1A1A2053601) and the research fund of Hanyang University (HY-2014).en_US
dc.language.isoenen_US
dc.publisherMARY ANN LIEBERTen_US
dc.subjectcaffeineen_US
dc.subjecthormoneen_US
dc.subjectlong boneen_US
dc.subjectpubertyen_US
dc.subjectraten_US
dc.titlePeripubertal Caffeine Exposure Impairs Longitudinal Bone Growth in Immature Male Rats in a Dose- and Time-Dependent Manneren_US
dc.typeArticleen_US
dc.relation.no1-
dc.relation.volume19-
dc.identifier.doi10.1089/jmf.2015.3467-
dc.relation.page73-84-
dc.relation.journalJOURNAL OF MEDICINAL FOOD-
dc.contributor.googleauthorChoi, Yun-Young-
dc.contributor.googleauthorChoi, Yuri-
dc.contributor.googleauthorKim, Jisook-
dc.contributor.googleauthorChoi, Hyeonhae-
dc.contributor.googleauthorShin, Jiwon-
dc.contributor.googleauthorRoh, Jaesook-
dc.relation.code2016001073-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidrohjaesook-
dc.identifier.researcherIDP-1689-2015-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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