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dc.contributor.authorHong, Jong Wook-
dc.date.accessioned2017-11-08T02:21:20Z-
dc.date.available2017-11-08T02:21:20Z-
dc.date.issued2016-01-
dc.identifier.citationANALYTICAL SCIENCES, v. 32, NO 1, Page. 67-73en_US
dc.identifier.issn0910-6340-
dc.identifier.issn1348-2246-
dc.identifier.urihttps://www.jstage.jst.go.jp/article/analsci/32/1/32_67/_article-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/30577-
dc.description.abstractIn recent years, a microfluidic technology has contributed a significant role in biological research, specifically for the study of biofilms. Bacterial biofilms are a source of infections and contamination in the environment due to an extra polymeric matrix. Inadequate uses of antibiotics make the bacterial biofilms antibiotic resistant. Therefore, it is important to determine the effective concentration of antibiotics in order to eliminate bacterial biofilms. The present microfluidic study was carried out to analyze the activities of tobramycin and sodium dodecyl sulfate (SDS) against Pseudomonas aeruginosa biofilms with a continuous flow in order to achieve a greater delivery of the agents. The results show that a co-treatment of tobramycin and SDS significantly reduced the biomass of biofilms (by more than 99%) after 24 h. Tobramycin and SDS killed and detached bacteria in the cores of biofilms. Evidently, our data suggest that a microchannel would be effective for both quantitative and qualitative evaluations in order to test combinatorial effect of drugs and chemicals on a complexed biological system including biofilm.en_US
dc.description.sponsorshipThis work was supported by the research fund of Hanyang University (HY-2013-201300000002248).en_US
dc.language.isoenen_US
dc.publisherJAPAN SOC ANALYTICAL CHEMISTRYen_US
dc.subjectMicrofluidicen_US
dc.subjectPseudomonas aeruginosaen_US
dc.subjectsodium dodecyl sulfateen_US
dc.subjecttobramycinen_US
dc.subjectconfocal laser scanning microscopeen_US
dc.titleA Microfluidic Approach to Investigating a Synergistic Effect of Tobramycin and Sodium Dodecyl Sulfate on Pseudomonas aeruginosa Biofilmsen_US
dc.typeArticleen_US
dc.relation.volume32-
dc.identifier.doi10.2116/analsci.32.67-
dc.relation.page67-73-
dc.relation.journalANALYTICAL SCIENCES-
dc.contributor.googleauthorShin, Soojeong-
dc.contributor.googleauthorAhmed, Ishtiaq-
dc.contributor.googleauthorHwang, Jangsun-
dc.contributor.googleauthorSeo, Youngmin-
dc.contributor.googleauthorLee, Eunwon-
dc.contributor.googleauthorChoi, Jonghoon-
dc.contributor.googleauthorMoon, Sangjun-
dc.contributor.googleauthorHong, Jong Wook-
dc.relation.code2016001936-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidjwh-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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