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dc.contributor.author신흥수-
dc.date.accessioned2017-11-07T04:39:40Z-
dc.date.available2017-11-07T04:39:40Z-
dc.date.issued2016-01-
dc.identifier.citationACS APPLIED MATERIALS & INTERFACES, v. 8, NO 5, Page. 3407-3417en_US
dc.identifier.issn1944-8244-
dc.identifier.urihttp://pubs.acs.org/doi/10.1021/acsami.5b11418-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/30527-
dc.description.abstractDeveloping an artificial extracellular matrix that closely mimics the native tissue microenvironment is important for use as both a cell culture platform for controlling cell fate and an in vitro model system for investigating the role of the cellular microenvironment. Electrospinning, one of the methods for fabricating structures that mimic the native ECM, is a promising technique for creating fibrous platforms. It is well-known that align or randomly distributed electrospun fibers provide cellular contact guidance in a single pattern. However, native tissues have hierarchical structures, i.e., topographies on the micro- and nanoscales, rather than a single structure. Thus, we fabricated randomly distributed nanofibrous (720 +/- 80 nm in diameter) platforms via a conventional electrospinning process, and then we generated microscale grooves using a femtosecond laser ablation process to develop engineered fibrous platforms with patterned hierarchical topographies. The engineered fibrous platforms can regulate cellular adhesive morphology, proliferation, and distinct distribution of focal adhesion proteins. Furthermore, confluent myoblasts cultured on the engineered fibrous platforms revealed that the direction of myotube assembly can be controlled. These results indicate that our engineered fibrous platforms may be useful tools in investigating the roles of nano- and microscale topographies in the communication between cells and ECM.en_US
dc.description.sponsorshipThis work was supported by Korea Institute of Science & Technology (KIST) project (Grant 2E26245) and a grant of National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (Grant NRF-2013R1A2A2A03067809).en_US
dc.language.isoenen_US
dc.publisherAMER CHEMICAL SOCen_US
dc.subjectECM (extracellular matrix)en_US
dc.subjecthierarchical topographiesen_US
dc.subjectnano/micro scaleen_US
dc.subjectelectrospinning femtosecond laseren_US
dc.titleCreating Hierarchical Topographies on Fibrous Platforms Using Femtosecond Laser Ablation for Directing Myoblasts Behavioren_US
dc.typeArticleen_US
dc.relation.no5-
dc.relation.volume8-
dc.identifier.doi10.1021/acsami.5b11418-
dc.relation.page3407-3417-
dc.relation.journalACS APPLIED MATERIALS & INTERFACES-
dc.contributor.googleauthorJun, Indong-
dc.contributor.googleauthorChung, Yong-Woo-
dc.contributor.googleauthorHeo, Yun-Hoe-
dc.contributor.googleauthorHan, Hyung-Seop-
dc.contributor.googleauthorPark, Jimin-
dc.contributor.googleauthorJeong, Hongsoo-
dc.contributor.googleauthorLee, Hyunjung-
dc.contributor.googleauthorLee, Yu Bin-
dc.contributor.googleauthorKim, Yu-Chan-
dc.contributor.googleauthorShin, Heungsoo-
dc.relation.code2016001740-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDEPARTMENT OF BIOENGINEERING-
dc.identifier.pidhshin-
dc.identifier.orcidhttp://orcid.org/0000-0001-6870-1485-
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COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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