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Aspirin induces IL-4 production: augmented IL-4 production in aspirin-exacerbated respiratory disease

Title
Aspirin induces IL-4 production: augmented IL-4 production in aspirin-exacerbated respiratory disease
Author
정일엽
Keywords
NF-KAPPA-B; INFLAMMATORY CELL-POPULATIONS; ACTIVATED PROTEIN-KINASE; LEUKOTRIENE C-4 SYNTHASE; HUMAN MAST-CELLS; HUMAN T-CELLS; CYSTEINYL-LEUKOTRIENES; SENSITIVE ASTHMATICS; SALICYLATES INHIBIT; SODIUM-SALICYLATE
Issue Date
2016-01
Publisher
NATURE PUBLISHING GROUP
Citation
EXPERIMENTAL AND MOLECULAR MEDICINE, v. 48, Page. 1-10
Abstract
Aspirin hypersensitivity is a hallmark of aspirin-exacerbated respiratory disease (AERD), a clinical syndrome characterized by the severe inflammation of the respiratory tract after ingestion of cyclooxygenase-1 inhibitors. We investigated the capacity of aspirin to induce interleukin-4 (IL-4) production in inflammatory cells relevant to AERD pathogenesis and examined the associated biochemical and molecular pathways. We also compared IL-4 production in peripheral blood mononuclear cells (PBMCs) from patients with AERD vs aspirin-tolerant asthma (ATA) upon exposure to aspirin. Aspirin induced IL-4 expression and activated the IL-4 promoter in a report assay. The capacity of aspirin to induce IL-4 expression correlated with its activity to activate mitogen-activated protein kinases, to form DNA-protein complexes on P elements in the IL-4 promoter and to synthesize nuclear factor of activated T cells, critical transcription factors for IL-4 transcription. Of clinical importance, aspirin upregulated IL-4 production twice as much in PBMCs from patients with AERD compared with PBMCs from patients with ATA. Our results suggest that IL-4 is an inflammatory component mediating intolerance reactions to aspirin, and thus is crucial for AERD pathogenesis.
URI
https://www.nature.com/emm/journal/v48/n1/full/emm201596a.htmlhttp://hdl.handle.net/20.500.11754/30516
ISSN
1226-3613; 2092-6413
DOI
10.1038/emm.2015.96
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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