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dc.contributor.author최동호-
dc.date.accessioned2017-11-01T06:52:23Z-
dc.date.available2017-11-01T06:52:23Z-
dc.date.issued2016-01-
dc.identifier.citationWORLD JOURNAL OF SURGERY, v. 40, NO 6, Page. 1412-1421en_US
dc.identifier.issn0364-2313-
dc.identifier.issn1432-2323-
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs00268-015-3396-7-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/30398-
dc.description.abstractCholecystectomy might contribute to the development of hepatic steatosis through metabolic changes. The biologic alteration of the enterohepatic circulation of bile acids and the alteration of the metabolic activity of bile acid that follows cholecystectomy may contribute to hepatic steatosis. This prospective study was conducted to clarify the possibility of steatosis development after cholecystectomy. From October 2013 to July 2014, 82 consecutive patients with a presumptive diagnosis of gallbladder disease were cholecystectomized. Liver parenchymal steatosis was measured using ultrasound and the hepatic steatosis index. In all 82 patients, the hepatic steatosis index was found to be significantly correlated with the US fatty liver grade (Spearman's correlation r (2) = 0.331, P < 0.001). A total of 62 patients were followed up for 3 months. Comparison with the initial grade showed that 12 (18.5 %) patients had worsened from normal to mild (n = 10), from mild to moderate (n = 1), and from mild to severe (n = 1). The other patients stayed at their initial grade except one patient who improved (from moderated to mild). Analysis of laboratory findings showed that white blood cell count, aspartate transaminase, alanine transaminase level, and total bilirubin level were decreased. However, serum albumin and high-density lipoprotein cholesterol levels significantly increased. Hepatic steatosis significantly developed 3 months after cholecystectomy. Therefore, cholecystectomy might be considered a risk factor for hepatic steatosis, but the relationship should be confirmed with long-term follow-up from a large group of patients.en_US
dc.description.sponsorshipThis work was carried out with the support of "Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ011002022015)" Rural Development Administration, Republic of Korea. This work was registered to U.S. National Institutes of Health (Clinicaltrials.gov Identifier: NCT02493153).en_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.subjectNONALCOHOLIC FATTY LIVERen_US
dc.subjectGROWTH-FACTOR 19en_US
dc.subjectGALLSTONE-DISEASEen_US
dc.subjectMETABOLIC SYNDROMEen_US
dc.subjectRISK-FACTORSen_US
dc.subjectBILEen_US
dc.subjectMICEen_US
dc.subjectSTEATOHEPATITISen_US
dc.subjectCHOLESTEROLen_US
dc.subjectPOPULATIONen_US
dc.titleCholecystectomy causes ultrasound evidence of increased hepatic steatosisen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s00268-015-3396-7-
dc.relation.page1-10-
dc.relation.journalWORLD JOURNAL OF SURGERY-
dc.contributor.googleauthorYun, Sangchul-
dc.contributor.googleauthorChoi, Dongho-
dc.contributor.googleauthorLee, Kyeong Geun-
dc.contributor.googleauthorKim, Han Joon-
dc.contributor.googleauthorKang, Bo-Kyeong-
dc.contributor.googleauthorKim, Hyunsung-
dc.contributor.googleauthorPaik, Seung Sam-
dc.relation.code2016002255-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidcrane87-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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