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dc.contributor.author심지원-
dc.date.accessioned2017-10-31T02:11:22Z-
dc.date.available2017-10-31T02:11:22Z-
dc.date.issued2016-01-
dc.identifier.citationBMB REPORTS, v. 49, NO 1, Page. 3-10en_US
dc.identifier.issn1976-6696-
dc.identifier.issn1976-670X-
dc.identifier.urihttp://koreascience.or.kr/article/ArticleFullRecord.jsp?cn=E1MBB7_2016_v49n1_3-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/30342-
dc.description.abstractmicroRNAs (miRNAs) are key regulators of cell state transition and retention during stem cell proliferation and differentiation by post-transcriptionally downregulating hundreds of conserved target genes via seed-pairing in their 3' untranslated region. In embryonic and adult stem cells, dozens of miRNAs that elaborately control stem cell processes by modulating the transcriptomic context therein have been identified. Some miRNAs accelerate the change of cell state into progenitor cell lineages-such as myoblast, myeloid or lymphoid progenitors, and neuro precursor stem cells-and other miRNAs decelerate the change but induce proliferative activity, resulting in cell state retention. This cell state choice can be controlled by endogenously or exogenously changing miRNA levels or by including or excluding target sites. This control of miRNA-mediated gene regulation could improve our understanding of stem cell biology and facilitate their development as therapeutic tools.en_US
dc.description.sponsorshipThis work was supported by the research fund of Hanyang University (HY-2012-2191) and by the "Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ01045303)" of the Rural Development Administration, Republic of Korea.en_US
dc.language.isoenen_US
dc.publisherKOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGYen_US
dc.subjectAdult stem cellen_US
dc.subjectDifferentiationen_US
dc.subjectEmbryonic stem cellen_US
dc.subjectmicroRNAen_US
dc.subjectProliferationen_US
dc.subjectSelf-renewalen_US
dc.titleThe expression and functional roles of microRNAs in stem cell differentiationen_US
dc.typeArticleen_US
dc.relation.no1-
dc.relation.volume49-
dc.identifier.doi10.5483/BMBRep.2016.49.1.217-
dc.relation.page3-10-
dc.relation.journalBMB REPORTS-
dc.contributor.googleauthorShim, Jiwon-
dc.contributor.googleauthorNam, Jin-Wu-
dc.relation.code2016010352-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidjshim-


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