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The expression and functional roles of microRNAs in stem cell differentiation

Title
The expression and functional roles of microRNAs in stem cell differentiation
Author
심지원
Keywords
Adult stem cell; Differentiation; Embryonic stem cell; microRNA; Proliferation; Self-renewal
Issue Date
2016-01
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Citation
BMB REPORTS, v. 49, NO 1, Page. 3-10
Abstract
microRNAs (miRNAs) are key regulators of cell state transition and retention during stem cell proliferation and differentiation by post-transcriptionally downregulating hundreds of conserved target genes via seed-pairing in their 3' untranslated region. In embryonic and adult stem cells, dozens of miRNAs that elaborately control stem cell processes by modulating the transcriptomic context therein have been identified. Some miRNAs accelerate the change of cell state into progenitor cell lineages-such as myoblast, myeloid or lymphoid progenitors, and neuro precursor stem cells-and other miRNAs decelerate the change but induce proliferative activity, resulting in cell state retention. This cell state choice can be controlled by endogenously or exogenously changing miRNA levels or by including or excluding target sites. This control of miRNA-mediated gene regulation could improve our understanding of stem cell biology and facilitate their development as therapeutic tools.
URI
http://koreascience.or.kr/article/ArticleFullRecord.jsp?cn=E1MBB7_2016_v49n1_3http://hdl.handle.net/20.500.11754/30342
ISSN
1976-6696; 1976-670X
DOI
10.5483/BMBRep.2016.49.1.217
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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