Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 장기석 | - |
dc.date.accessioned | 2017-10-24T06:28:25Z | - |
dc.date.available | 2017-10-24T06:28:25Z | - |
dc.date.issued | 2015-12 | - |
dc.identifier.citation | JOURNAL OF BREAST CANCER, v. 18, NO 4, Page. 323-328 | en_US |
dc.identifier.issn | 1738-6756 | - |
dc.identifier.issn | 2092-9900 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.4048/jbc.2015.18.4.323 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/30234 | - |
dc.description.abstract | Purpose: Deregulation of microRNA-370 (miR-370) has been reported in various cancers, in which it can act as either an oncogene or a tumor suppressor gene. However, the clinicopathologic significance of miR-370 expression in breast cancer has not been studied. Methods: The expression of miR-370 was determined with quantitative real-time polymerase chain reaction in 60 formalin-fixed, paraffin-embedded primary breast cancer tissues. Additionally, the protein expression levels of previously known targets of miR-370, such as FOXM1, FOXO1, and FOXO3a, were detected using immunohistochemistry. Finally, we analyzed its correlation with target protein expression, clinicopathologic features, and clinical outcome. Results: High levels of miR-370 expression correlated with lymph node metastasis (p=0.009), advanced stage (p=0.002), and frequent perineural invasion (p=0.042). Moreover, patients with high miR-370 expression had poor disease-free survival compared with the low-expression group. However, no correlation was observed between miR-370 and its target protein expression. Conclusion: Our results indicate that upregulation of miR-370 in breast cancer is correlated with breast cancer progression and that it might be a potential biomarker for predicting clinical outcomes. | en_US |
dc.description.sponsorship | This study was supported by a grant from the research fund of Hanyang University (HY-2012-MC) to Kiseok Jang. | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN BREAST CANCER SOC | en_US |
dc.subject | Breast neoplasms | en_US |
dc.subject | MicroRNA-370 | en_US |
dc.subject | Prognosis | en_US |
dc.subject | Real-time polymerase chain reaction | en_US |
dc.title | High MicroRNA-370 Expression Correlates with Tumor Progression and Poor Prognosis in Breast Cancer | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 18 | - |
dc.identifier.doi | 10.4048/jbc.2015.18.4.323 | - |
dc.relation.page | 323-328 | - |
dc.relation.journal | JOURNAL OF BREAST CANCER | - |
dc.contributor.googleauthor | Sim, Jongmin | - |
dc.contributor.googleauthor | Ahn, Hyein | - |
dc.contributor.googleauthor | Abdul, Rehman | - |
dc.contributor.googleauthor | Kim, Hyunsung | - |
dc.contributor.googleauthor | Yi, Ki-jong | - |
dc.contributor.googleauthor | Chung, Yu-min | - |
dc.contributor.googleauthor | Chung, Min Sung | - |
dc.contributor.googleauthor | Paik, Seung Sam | - |
dc.contributor.googleauthor | Song, Young Soo | - |
dc.contributor.googleauthor | Jang, Kiseok | - |
dc.relation.code | 2015013009 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | medartisan | - |
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