382 75

Full metadata record

DC FieldValueLanguage
dc.contributor.author정민성-
dc.date.accessioned2017-10-24T05:21:55Z-
dc.date.available2017-10-24T05:21:55Z-
dc.date.issued2015-12-
dc.identifier.citationJOURNAL OF BREAST CANCERen_US
dc.identifier.issn1738-6756-
dc.identifier.issn2092-9900-
dc.identifier.urihttps://synapse.koreamed.org/DOIx.php?id=10.4048/jbc.2015.18.4.323-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/30225-
dc.description.abstractPurpose: Deregulation of microRNA-370 (miR-370) has been reported in various cancers, in which it can act as either an oncogene or a tumor suppressor gene. However, the clinicopathologic significance of miR-370 expression in breast cancer has not been studied. Methods: The expression of miR-370 was determined with quantitative real-time polymerase chain reaction in 60 formalin-fixed, paraffin-embedded primary breast cancer tissues. Additionally, the protein expression levels of previously known targets of miR-370, such as FOXM1, FOXO1, and FOXO3a, were detected using immunohistochemistry. Finally, we analyzed its correlation with target protein expression, clinicopathologic features, and clinical outcome. Results: High levels of miR-370 expression correlated with lymph node metastasis (p=0.009), advanced stage (p=0.002), and frequent perineural invasion (p=0.042). Moreover, patients with high miR-370 expression had poor disease-free survival compared with the low-expression group. However, no correlation was observed between miR-370 and its target protein expression. Conclusion: Our results indicate that upregulation of miR-370 in breast cancer is correlated with breast cancer progression and that it might be a potential biomarker for predicting clinical outcomes.en_US
dc.description.sponsorshipThis study was supported by a grant from the research fund of Hanyang University (HY-2012-MC) to Kiseok Jang.en_US
dc.language.isoenen_US
dc.publisherKOREAN BREAST CANCER SOCen_US
dc.subjectBreast neoplasmsen_US
dc.subjectMicroRNA-370en_US
dc.subjectPrognosisen_US
dc.subjectReal-time polymerase chain reactionen_US
dc.titleHigh MicroRNA-370 Expression Correlates with Tumor Progression and Poor Prognosis in Breast Canceren_US
dc.typeArticleen_US
dc.identifier.doi10.4048/jbc.2015.18.4.323-
dc.relation.journalJOURNAL OF BREAST CANCER-
dc.contributor.googleauthorSim, Jongmin-
dc.contributor.googleauthorAhn, Hyein-
dc.contributor.googleauthorAbdul, Rehman-
dc.contributor.googleauthorKim, Hyunsung-
dc.contributor.googleauthorYi, Ki-jong-
dc.contributor.googleauthorChung, Yu-min-
dc.contributor.googleauthorChung, Min Sung-
dc.contributor.googleauthorPaik, Seung Sam-
dc.contributor.googleauthorSong, Young Soo-
dc.contributor.googleauthorJang, Kiseok-
dc.relation.code2015013009-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidbovie-


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE