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A novel peptide-based recognition probe for the sensitive detection of CD44 on breast cancer stem cells

Title
A novel peptide-based recognition probe for the sensitive detection of CD44 on breast cancer stem cells
Author
이수재
Keywords
CD44; Breast cancer stem cell; Peptide; PDPP
Issue Date
2015-12
Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Citation
MOLECULAR AND CELLULAR PROBES, v. 29, NO 6, Page. 492-499
Abstract
Metastasis and recurrence of breast cancer remain significant clinical problems. The expression level of CD44 protein is higher in breast cancer-initiating cancer stem cells; therefore, the early detection of CD44 using a sensitive diagnostic probe is important for breast cancer diagnosis and therapeutic purposes. In this study, we fabricated a polyvalent directed peptide polymer (PDPP) that specifically recognized the CD44 biomarker, as confirmed by immunocytochemistry tests and fluorescence-activated cell sorting assessment. Our results indicate that PDPP is useful as a novel tool for the sensitive detection of breast cancer stem cells. (C) 2015 Elsevier Ltd. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S0890850815300104?via%3Dihubhttp://hdl.handle.net/20.500.11754/30221
ISSN
0890-8508
DOI
10.1016/j.mcp.2015.05.014
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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