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Immunomodulatory properties of stem cells and bioactive molecules for tissue engineering

Title
Immunomodulatory properties of stem cells and bioactive molecules for tissue engineering
Author
신흥수
Keywords
Mesenchymal stem cell; Immunomodulation; Cell delivery; Bioactive molecules; Tissue engineering; Regenerative medicine
Issue Date
2015-12
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF CONTROLLED RELEASE, v. 219, Page. 107-118
Abstract
The immune system plays a crucial role in the success of tissue engineering strategies. Failure to consider the interactions between implantable scaffolds, usually containing cells and/or bioactive molecules, and the immune system can result in rejection of the implant and devastating clinical consequences. However, recent research into mesenchymal stem cells, which are commonly used in many tissue engineering applications, indicates that they may play a beneficial role modulating the immune system. Likewise, direct delivery of bioactive molecules involved in the inflammatory process can promote the success of tissue engineering constructs. In this article, we will review the various mechanisms in which modulation of the immune system is achieved through delivered bioactive molecules and cells and contextualize this information for future strategies in tissue engineering. (C) 2015 Elsevier B.V. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S016836591530081Xhttp://hdl.handle.net/20.500.11754/30218
ISSN
0168-3659; 1873-4995
DOI
10.1016/j.jconrel.2015.08.038
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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