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Tuning the sphere-to-rod transition in the self-assembly of thermoresponsive polymer hybrids

Title
Tuning the sphere-to-rod transition in the self-assembly of thermoresponsive polymer hybrids
Author
이근용
Keywords
Sphere; Rod; Thermoreversible; Self-assembly; Alginate; Poly(N-isopropylaciylamide)
Issue Date
2015-12
Publisher
ELSEVIER SCIENCE BV
Citation
COLLOIDS AND SURFACES B-BIOINTERFACES, v. 136, Page. 612-617
Abstract
Nano-scale drug delivery systems have undergone extensive development, and control of size and structure is critical for regulation of their biological responses and therapeutic efficacy. Amphiphilic polymers that form self-assembled structures in aqueous media have been investigated and used for the diagnosis and therapy of various diseases, including cancer. Here, we report the design and fabrication of thermoresponsive polymeric micelles from alginate conjugated with poly(N-isopropylacrylamide) (PNIPAAm). Alginate-PNIPAAm hybrids formed self-aggregated structures in response to temperature changes near body temperature. A structural transition from micellar spheres to rods of alginate-PNIPAAm hybrids was observed depending on the molecular weight of PNIPAAm and the polymer concentration. Additionally, hydrogels with nanofibrous structures were formed by simply increasing the polymer concentration. This approach to controlling the structure of polymer micelles from nanoparticles to fibrous hydrogels may be useful in applications in drug delivery and tissue engineering. (C) 2015 Elsevier B.V. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S0927776515302290?via%3Dihubhttp://hdl.handle.net/20.500.11754/30210
ISSN
0927-7765; 1873-4367
DOI
10.1016/j.colsurfb.2015.09.060
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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