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dc.contributor.author이학준-
dc.date.accessioned2017-10-20T01:39:55Z-
dc.date.available2017-10-20T01:39:55Z-
dc.date.issued2015-12-
dc.identifier.citationBULLETIN OF THE KOREAN CHEMICAL SOCIETY, v. 36, NO 12, Page. 2885-2889en_US
dc.identifier.issn0253-2964-
dc.identifier.issn1229-5949-
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1002/bkcs.10592/abstract-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/30132-
dc.description.abstractThe competitive muscarinic receptor antagonist fesoterodine is a congener of tolterodine and has better efficiency compared to tolterodine. In this study, we present an efficient synthesis of the fesoterodine intermediate 3-(3-diisopropylamino-1-phenylpropyl)-4-hydroxybenzaldehyde from ethyl benzoylacetate by Friedel-Crafts alkylation in the presence of an acid as a key reaction step. The synthesis is carried out by the reduction of the ketoester to a 1,3-diol, diisopropylamine substitution, and Friedel-Crafts alkylation, followed by reduction and chiral resolution.en_US
dc.description.sponsorshipY. Lee, Y. Jeong, and J. Ban acknowledge financial support from the Korean Ministry of Education through BK21-Plus Project for the Hanyang University Graduate Program.en_US
dc.language.isoenen_US
dc.publisherKOREAN CHEMICAL SOCen_US
dc.subjectElectrophilic aromatic substitutionen_US
dc.subjectChiral resolutionen_US
dc.subjectReductionen_US
dc.subjectAcylationen_US
dc.subjectSulfonationen_US
dc.titleFormal Synthesis of Fesoterodine by Acid-Facilitated Aromatic Alkylationen_US
dc.typeArticleen_US
dc.relation.no12-
dc.relation.volume36-
dc.identifier.doi10.1002/bkcs.10592-
dc.relation.page2885-2889-
dc.relation.journalBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.contributor.googleauthorLee, Youngeun-
dc.contributor.googleauthorShabbir, Saira-
dc.contributor.googleauthorJeong, Yuri-
dc.contributor.googleauthorBan, Jaeyoung-
dc.contributor.googleauthorRhee, Hakjune-
dc.relation.code2015003699-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidhrhee-
dc.identifier.researcherIDO-5765-2017-
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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