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dc.contributor.author배상철-
dc.date.accessioned2017-10-18T01:30:20Z-
dc.date.available2017-10-18T01:30:20Z-
dc.date.issued2015-12-
dc.identifier.citationCELLULAR AND MOLECULAR BIOLOGY, v. 61, NO 8, Page. 105-111en_US
dc.identifier.issn0145-5680-
dc.identifier.issn1165-158X-
dc.identifier.urihttps://www.cellmolbiol.org/index.php/CMB/article/view/766-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/30090-
dc.description.abstractThis study determined whether interleukin-1 (IL-1) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA). A meta-analysis was conducted on the associations between the IL-1A, IL-1B, and IL-1 receptor antagonist (IL-1RN) polymorphisms and RA. A total of 16 studies involving 4,339 RA cases and 3,885 controls were included in the meta-analysis. Meta-analysis of the IL-1B -511 C/T polymorphism revealed an association between the IL-1B -511 T allele and RA in Caucasians (OR = 0.913, 95% CI = 0.840-0.992, p = 0.031), but not in Asians. Ethnicity-specific meta-analysis indicated an association between the TT+TC genotype of the IL-1B 3953 C/T polymorphism and RA in Caucasians (OR = 1.243, 95% CI = 1.008-1.533, p = 0.042) and in Asians (OR = 2.672, 95% CI = 1.662-4.296, p = 4.9x10(-6)). No association was between RA susceptibility and the IL-1A -889 C/T, IL-1A + 4845 G/T, and IL-1RN + 2018 C/T polymorphisms. This meta-analysis suggests the IL-1B -511 C/T polymorphism is associated with susceptibility to RA in Caucasians, and that the IL-1B + 3953 C/T polymorphism is associated with susceptibility to RA in Caucasians and Asians.en_US
dc.description.sponsorshipThis study was supported in part by a grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI13C2124).en_US
dc.language.isoenen_US
dc.publisherC M B ASSOCen_US
dc.subjectRheumatoid arthritisen_US
dc.subjectInterleukin-1en_US
dc.subjectPolymorphismen_US
dc.subjectMeta-analysisen_US
dc.titleAssociations between interleukin-1 and IL-1 receptor antagonist polymorphisms and susceptibility to rheumatoid arthritis: A meta-analysisen_US
dc.typeArticleen_US
dc.relation.no8-
dc.relation.volume61-
dc.relation.page105-111-
dc.relation.journalCELLULAR AND MOLECULAR BIOLOGY-
dc.contributor.googleauthorLee, Y. H .-
dc.contributor.googleauthorBae, S-C.-
dc.relation.code2015001313-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidscbae-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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