Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2017-10-18T01:30:20Z | - |
dc.date.available | 2017-10-18T01:30:20Z | - |
dc.date.issued | 2015-12 | - |
dc.identifier.citation | CELLULAR AND MOLECULAR BIOLOGY, v. 61, NO 8, Page. 105-111 | en_US |
dc.identifier.issn | 0145-5680 | - |
dc.identifier.issn | 1165-158X | - |
dc.identifier.uri | https://www.cellmolbiol.org/index.php/CMB/article/view/766 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/30090 | - |
dc.description.abstract | This study determined whether interleukin-1 (IL-1) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA). A meta-analysis was conducted on the associations between the IL-1A, IL-1B, and IL-1 receptor antagonist (IL-1RN) polymorphisms and RA. A total of 16 studies involving 4,339 RA cases and 3,885 controls were included in the meta-analysis. Meta-analysis of the IL-1B -511 C/T polymorphism revealed an association between the IL-1B -511 T allele and RA in Caucasians (OR = 0.913, 95% CI = 0.840-0.992, p = 0.031), but not in Asians. Ethnicity-specific meta-analysis indicated an association between the TT+TC genotype of the IL-1B 3953 C/T polymorphism and RA in Caucasians (OR = 1.243, 95% CI = 1.008-1.533, p = 0.042) and in Asians (OR = 2.672, 95% CI = 1.662-4.296, p = 4.9x10(-6)). No association was between RA susceptibility and the IL-1A -889 C/T, IL-1A + 4845 G/T, and IL-1RN + 2018 C/T polymorphisms. This meta-analysis suggests the IL-1B -511 C/T polymorphism is associated with susceptibility to RA in Caucasians, and that the IL-1B + 3953 C/T polymorphism is associated with susceptibility to RA in Caucasians and Asians. | en_US |
dc.description.sponsorship | This study was supported in part by a grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI13C2124). | en_US |
dc.language.iso | en | en_US |
dc.publisher | C M B ASSOC | en_US |
dc.subject | Rheumatoid arthritis | en_US |
dc.subject | Interleukin-1 | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | Meta-analysis | en_US |
dc.title | Associations between interleukin-1 and IL-1 receptor antagonist polymorphisms and susceptibility to rheumatoid arthritis: A meta-analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 8 | - |
dc.relation.volume | 61 | - |
dc.relation.page | 105-111 | - |
dc.relation.journal | CELLULAR AND MOLECULAR BIOLOGY | - |
dc.contributor.googleauthor | Lee, Y. H . | - |
dc.contributor.googleauthor | Bae, S-C. | - |
dc.relation.code | 2015001313 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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