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Associations between interleukin-1 and IL-1 receptor antagonist polymorphisms and susceptibility to rheumatoid arthritis: A meta-analysis

Title
Associations between interleukin-1 and IL-1 receptor antagonist polymorphisms and susceptibility to rheumatoid arthritis: A meta-analysis
Author
배상철
Keywords
Rheumatoid arthritis; Interleukin-1; Polymorphism; Meta-analysis
Issue Date
2015-12
Publisher
C M B ASSOC
Citation
CELLULAR AND MOLECULAR BIOLOGY, v. 61, NO 8, Page. 105-111
Abstract
This study determined whether interleukin-1 (IL-1) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA). A meta-analysis was conducted on the associations between the IL-1A, IL-1B, and IL-1 receptor antagonist (IL-1RN) polymorphisms and RA. A total of 16 studies involving 4,339 RA cases and 3,885 controls were included in the meta-analysis. Meta-analysis of the IL-1B -511 C/T polymorphism revealed an association between the IL-1B -511 T allele and RA in Caucasians (OR = 0.913, 95% CI = 0.840-0.992, p = 0.031), but not in Asians. Ethnicity-specific meta-analysis indicated an association between the TT+TC genotype of the IL-1B 3953 C/T polymorphism and RA in Caucasians (OR = 1.243, 95% CI = 1.008-1.533, p = 0.042) and in Asians (OR = 2.672, 95% CI = 1.662-4.296, p = 4.9x10(-6)). No association was between RA susceptibility and the IL-1A -889 C/T, IL-1A + 4845 G/T, and IL-1RN + 2018 C/T polymorphisms. This meta-analysis suggests the IL-1B -511 C/T polymorphism is associated with susceptibility to RA in Caucasians, and that the IL-1B + 3953 C/T polymorphism is associated with susceptibility to RA in Caucasians and Asians.
URI
https://www.cellmolbiol.org/index.php/CMB/article/view/766http://hdl.handle.net/20.500.11754/30090
ISSN
0145-5680; 1165-158X
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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