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dc.contributor.author배상철-
dc.date.accessioned2017-10-18T01:19:11Z-
dc.date.available2017-10-18T01:19:11Z-
dc.date.issued2015-12-
dc.identifier.citationCELLULAR AND MOLECULAR BIOLOGY, v. 61, NO 8, Page. 24-30en_US
dc.identifier.issn0145-5680-
dc.identifier.issn1165-158X-
dc.identifier.urihttps://www.cellmolbiol.org/index.php/CMB/article/view/753-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/30088-
dc.description.abstractThe aim of this study was to determine whether a functional human leukocyte antigen-G (HLA-G) 14-bp insertion (I)/deletion (D) polymorphism is associated with susceptibility to autoimmune diseases. A meta-analysis was conducted to assess the association between an HLA-G 14-bp I/D polymorphism and autoimmune diseases using 1) allele contrast, as well as 2) recessive, 3) dominant, and 4) codominant models. Sixteen articles that included 20 comparative studies with 3,555 patients and 5,225 controls were included in the meta-analysis. These studies were performed on nine Caucasian, six South American, three Asian, one Arab, and one African population samples. Our meta-analysis revealed no association between autoimmune diseases and the HLA-G 14-bp I/D polymorphism [odds ratio (OR) for allele I = 1.055; 95% confidence interval (CI) = 0.963–1.156; p = 0.251)]. However, meta-analysis according to autoimmune disease type revealed an association between systemic lupus erythematosus (SLE) and the II+ID genotype of the HLA-G 14-bp I/D polymorphism (OR = 1.205; 95% CI = 1.036–1.403; p = 0.016). Furthermore, analysis using a codominant model revealed an association between this polymorphism and SLE (OR for ID vs. DD = 1.203; 95% CI = 1.024–1.413; p = 0.024). In contrast, our meta-analysis revealed no association between rheumatoid arthritis (RA), multiple sclerosis (MS), or Crohn’s disease (CD) and the HLA-G 14-bp I/D polymorphism. This meta-analysis showed that the HLA-G 14-bp I/D polymorphism is associated with susceptibility to a subgroup of autoimmune diseases such as SLE, but not RA, MS, or CD. These results support the existence of an association between the HLA-G gene and a subgroup of autoimmune diseases.en_US
dc.description.sponsorshipThis study was supported in part by a grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI13C2124).-
dc.language.isoenen_US
dc.publisherC M B ASSOCen_US
dc.subjectAutoimmune diseasesen_US
dc.subjectHLA-Gen_US
dc.subjectPolymorphismen_US
dc.subjectMeta-analysisen_US
dc.titleAssociation between a Functional HLA-G 14-bp Insertion/deletion Polymorphism and Susceptibility to Autoimmune Diseases: A Meta-analysisen_US
dc.typeArticleen_US
dc.relation.no8-
dc.relation.volume61-
dc.relation.page24-30-
dc.relation.journalCELLULAR AND MOLECULAR BIOLOGY-
dc.contributor.googleauthorLee, Y. H.-
dc.contributor.googleauthorBae, S-C.-
dc.relation.code2015001313-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidscbae-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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