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dc.contributor.author김정목-
dc.date.accessioned2017-10-16T05:34:30Z-
dc.date.available2017-10-16T05:34:30Z-
dc.date.issued2015-12-
dc.identifier.citationANTIMICROBIAL AGENTS AND CHEMOTHERAPY, v. 59, NO 12, Page. 7629-7636en_US
dc.identifier.issn0066-4804-
dc.identifier.issn1098-6596-
dc.identifier.urihttp://aac.asm.org/content/59/12/7629-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/30044-
dc.description.abstractFinafloxacin is a novel fluoroquinolone with improved antimicrobial efficacy, especially in an acidic environment. The efficacy of finafloxacin for the inhibition of Helicobacter pylori infection was compared with the efficacies of levofloxacin and moxifloxacin at neutral and acidic pH. The impacts of gyrA point mutation on the efficacy of those three fluoroquinolones were also investigated. A total of 128 clinical H. pylori strains were utilized. MICs of levofloxacin, moxifloxacin, and finafloxacin were determined at pH 5.0 and pH 7.0 by the agar dilution method. The impact of gyrA point mutations that are responsible for fluoroquinolone resistance was analyzed; the results showed 50 strains with an Asn-87 point mutation, 48 strains with an Asp-91 point mutation, and the remaining 30 strains with no gyrA mutations. The use of finafloxacin led to MIC values at pH 5.0 that were lower than the values seen at pH 7.0 for 112 strains (112/128, 87.5%), and this proportion was higher than that seen with moxifloxacin (21/128, 16.4%, P < 0.001). Finafloxacin also demonstrated a rate of susceptibility (MIC,< 1 mu g/ml) (37.5%, 48/128) at pH 5.0 that was higher than that seen with moxifloxacin (2.3%, 3/128) (P < 0.001). The trends were similar regardless of which of the Asn-87, Asp-91, and A2143 point mutations were present. In conclusion, the superior antimicrobial efficacy of finafloxacin against H. pylori in an acidic environment suggests the possible use of finafloxacin for treatment of H. pylori infection, as has been proposed by its developer, Merlion Pharma.en_US
dc.description.sponsorshipThis work was supported by grant no 06-2012-221 from the Seoul National University Bundang Hospital Research fund.en_US
dc.language.isoenen_US
dc.publisherAMER SOC MICROBIOLOGYen_US
dc.subjectANTIBIOTIC-RESISTANCEen_US
dc.subjectTRIPLE THERAPYen_US
dc.subjectANTIMICROBIAL RESISTANCEen_US
dc.subjectERADICATION RATEen_US
dc.subjectGYRA MUTATIONen_US
dc.subjectINFECTIONen_US
dc.subjectKOREAen_US
dc.subjectCLARITHROMYCINen_US
dc.subjectLEVOFLOXACINen_US
dc.subjectSITAFLOXACINen_US
dc.titleHigh Efficacy of Finafloxacin on Helicobacter pylori Isolates at pH 5.0 Compared with That of Other Fluoroquinolonesen_US
dc.typeArticleen_US
dc.relation.no12-
dc.relation.volume59-
dc.identifier.doi10.1128/AAC.01467-15-
dc.relation.page7629-7636-
dc.relation.journalANTIMICROBIAL AGENTS AND CHEMOTHERAPY-
dc.contributor.googleauthorLee, Jung Won-
dc.contributor.googleauthorKim, Nayoung-
dc.contributor.googleauthorNam, Ryoung Hee-
dc.contributor.googleauthorKim, Jung Mogg-
dc.contributor.googleauthorPark, Jong Youn-
dc.contributor.googleauthorLee, Sun Min-
dc.contributor.googleauthorKim, Joo Sung-
dc.contributor.googleauthorLee, Dong Ho-
dc.contributor.googleauthorJung, Hyun Chae-
dc.relation.code2015001908-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidjungmogg-
dc.identifier.orcidhttp://orcid.org/0000-0002-6506-7519-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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