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dc.contributor.author윤채옥-
dc.date.accessioned2017-10-13T06:35:12Z-
dc.date.available2017-10-13T06:35:12Z-
dc.date.issued2015-12-
dc.identifier.citationJOURNAL OF CONTROLLED RELEASE, v. 219, Page. 181-191en_US
dc.identifier.issn0168-3659-
dc.identifier.issn1873-4995-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0168365915301784?via%3Dihub-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/29624-
dc.description.abstractOncolytic adenovirus (Ad) vectors present a promising modality to treat cancer. Many clinical trials have been done with either naked oncolytic Ad or combination with chemotherapies. However, the systemic injection of oncolytic Ad in clinical applications is restricted due to significant liver toxicity and immunogenicity. To overcome these issues, Ad has been engineered physically or chemically with numerous polymers for shielding the Ad surface, accomplishing extended blood circulation time and reduced immunogenicity as well as hepatotoxicity. In this review, we describe and classify the characteristics of polymer modified oncolytic Ad following each strategy for cancer treatment. Furthermore, this review concludes with the highlights of various polymer-coated Ads and their prospects, and directions for future research. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by grants from the National Research Foundation of Korea (2010-0029220, 2013M3A9D3045879 to CO Yun), and the National Institutes of Health, USA (CA177932 to SW Kim).en_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectOncolytic adenovirusen_US
dc.subjectClinical trialsen_US
dc.subjectCancer gene therapyen_US
dc.subjectOncolytic Ad/polymer hybrid vectoren_US
dc.subjectActive targetingen_US
dc.subjectTumor microenvironment targetingen_US
dc.subjectSystemic administrationen_US
dc.titlePolymeric oncolytic adenovirus for cancer gene therapyen_US
dc.typeArticleen_US
dc.relation.volume219-
dc.identifier.doi10.1016/j.jconrel.2015.10.009-
dc.relation.page181-191-
dc.relation.journalJOURNAL OF CONTROLLED RELEASE-
dc.contributor.googleauthorChoi, Joung-Woo-
dc.contributor.googleauthorLee, Young Sook-
dc.contributor.googleauthorYun, Chae-Ok-
dc.contributor.googleauthorKim, Sung Wan-
dc.relation.code2015002880-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDEPARTMENT OF BIOENGINEERING-
dc.identifier.pidchaeok-
dc.identifier.orcidhttp://orcid.org/0000-0002-9466-4531-
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COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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