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Polymeric oncolytic adenovirus for cancer gene therapy

Title
Polymeric oncolytic adenovirus for cancer gene therapy
Author
윤채옥
Keywords
Oncolytic adenovirus; Clinical trials; Cancer gene therapy; Oncolytic Ad/polymer hybrid vector; Active targeting; Tumor microenvironment targeting; Systemic administration
Issue Date
2015-12
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF CONTROLLED RELEASE, v. 219, Page. 181-191
Abstract
Oncolytic adenovirus (Ad) vectors present a promising modality to treat cancer. Many clinical trials have been done with either naked oncolytic Ad or combination with chemotherapies. However, the systemic injection of oncolytic Ad in clinical applications is restricted due to significant liver toxicity and immunogenicity. To overcome these issues, Ad has been engineered physically or chemically with numerous polymers for shielding the Ad surface, accomplishing extended blood circulation time and reduced immunogenicity as well as hepatotoxicity. In this review, we describe and classify the characteristics of polymer modified oncolytic Ad following each strategy for cancer treatment. Furthermore, this review concludes with the highlights of various polymer-coated Ads and their prospects, and directions for future research. (C) 2015 Elsevier B.V. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S0168365915301784?via%3Dihubhttp://hdl.handle.net/20.500.11754/29624
ISSN
0168-3659; 1873-4995
DOI
10.1016/j.jconrel.2015.10.009
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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