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dc.contributor.author최재훈-
dc.date.accessioned2017-10-13T06:27:32Z-
dc.date.available2017-10-13T06:27:32Z-
dc.date.issued2015-12-
dc.identifier.citationONCOGENE, v. 34, NO 50, Page. 6055-6065en_US
dc.identifier.issn0950-9232-
dc.identifier.issn1476-5594-
dc.identifier.urihttp://www.nature.com/onc/journal/v34/n50/full/onc201554a.html?foxtrotcallback=true-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/29623-
dc.description.abstractExtracellular Matrix Protein 1 (ECM1) is a marker for tumorigenesis and is correlated with invasiveness and poor prognosis in various types of cancer. However, the functional role of ECM1 in cancer metastasis is unclear. Here, we detected high ECM1 level in breast cancer patient sera that was associated with recurrence of tumor. The modulation of ECM1 expression affected not only cell migration and invasion, but also sphere-forming ability and drug resistance in breast cancer cell lines. In addition, ECM1 regulated the gene expression associated with the epithelial to mesenchymal transition (EMT) progression and cancer stem cell (CSC) maintenance. Interestingly, ECM1 increased beta-catenin expression at the post-translational level through induction of MUC1, which was physically associated with beta-catenin. Indeed, the association between beta-catenin and the MUC1 cytoplasmic tail was increased by ECM1. Furthermore, forced expression of beta-catenin altered the gene expression that potentiated EMT progression and CSC phenotype maintenance in the cells. These data provide evidence that ECM1 has an important role in cancer metastasis through beta-catenin stabilization.en_US
dc.description.sponsorshipThis work was supported by an NRF grant (2013-059143) from the Korea Research Foundation and Converging Research Center Program (2014048814).en_US
dc.language.isoenen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.subjectEXTRACELLULAR-MATRIX PROTEIN-1en_US
dc.subjectNF-KAPPA-Ben_US
dc.subjectEPITHELIAL-MESENCHYMAL TRANSITIONen_US
dc.subjectBREAST-CANCER CELLSen_US
dc.subjectSTEM-CELLSen_US
dc.subjectLYMPHATIC METASTASISen_US
dc.subjectSIGNALING PATHWAYSen_US
dc.subjectINITIATING CELLSen_US
dc.subjectSELF-RENEWALen_US
dc.subjectEXPRESSIONen_US
dc.titleECM1 regulates tumor metastasis and CSC-like property through stabilization of beta-cateninen_US
dc.typeArticleen_US
dc.relation.no50-
dc.relation.volume34-
dc.identifier.doi10.1038/onc.2015.54-
dc.relation.page6055-6065-
dc.relation.journalONCOGENE-
dc.contributor.googleauthorLee, K-m-
dc.contributor.googleauthorNam, K.-
dc.contributor.googleauthorOh, S.-
dc.contributor.googleauthorLim, J.-
dc.contributor.googleauthorKim, R. K.-
dc.contributor.googleauthorShim, D.-
dc.contributor.googleauthorChoi, J-h-
dc.contributor.googleauthorLee, S-J-
dc.contributor.googleauthorYu, J-H-
dc.contributor.googleauthorLee, J. W.-
dc.relation.code2015000098-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidjchoi75-
dc.identifier.researcherIDR-6224-2016-
dc.identifier.orcidhttp://orcid.org/0000-0002-5265-3463-
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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