Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김상헌 | - |
dc.date.accessioned | 2017-10-12T04:46:06Z | - |
dc.date.available | 2017-10-12T04:46:06Z | - |
dc.date.issued | 2015-12 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE, v. 47, Article number e198, Page. 198-205 | en_US |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.issn | 2092-6413 | - |
dc.identifier.uri | https://www.nature.com/emm/journal/v47/n12/full/emm201591a.html | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/29595 | - |
dc.description.abstract | Airway remodeling is a key characteristic of chronic asthma, particularly in patients with a fixed airflow limitation. The mechanisms underlying airway remodeling are poorly understood, and no therapeutic option is available. The Wnt/beta-catenin signaling pathway is involved in various physiological and pathological processes, including fibrosis and smooth muscle hypertrophy. In this study, we investigated the roles of Wnt/beta-catenin signaling in airway remodeling in patients with asthma. Wnt7a mRNA expression was prominent in induced sputum from patients with asthma compared with that from healthy controls. Next, we induced a chronic asthma mouse model with airway remodeling features, including subepithelial fibrosis and airway smooth muscle hyperplasia. Higher expression of Wnt family proteins and beta-catenin was detected in the lung tissue of mice with chronic asthma compared to control mice. Blocking beta-catenin expression with a specific siRNA attenuated airway inflammation and airway remodeling. Decreased subepithelial fibrosis and collagen accumulation in the beta-catenin siRNA-treated mice was accompanied by reduced expression of transforming growth factor-beta. We further showed that suppressing beta-catenin in the chronic asthma model inhibited smooth muscle hyperplasia by downregulating the tenascin C/platelet-derived growth factor receptor pathway. Taken together, these findings demonstrate that the Wnt/beta-catenin signaling pathway is highly expressed and regulates the development of airway remodeling in chronic asthma. | en_US |
dc.description.sponsorship | This study was supported by a National Research Foundation of Korea Grant from the Korean Government (NRF-2012S1A2A1A01031801). | en_US |
dc.language.iso | en | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | PULMONARY ARTERIAL-HYPERTENSION | en_US |
dc.subject | SMOOTH-MUSCLE-CELLS | en_US |
dc.subject | WNT PATHWAY | en_US |
dc.subject | FIBROSIS | en_US |
dc.subject | LUNG | en_US |
dc.subject | DISEASES | en_US |
dc.subject | BETA | en_US |
dc.subject | INFLAMMATION | en_US |
dc.subject | EXPRESSION | en_US |
dc.subject | TARGET | en_US |
dc.title | The Wnt/beta-catenin signaling pathway regulates the development of airway remodeling in patients with asthma | en_US |
dc.type | Article | en_US |
dc.relation.volume | 47 | - |
dc.identifier.doi | 10.1038/emm.2015.91 | - |
dc.relation.page | 198-205 | - |
dc.relation.journal | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.contributor.googleauthor | Kwak, Hyun Jung | - |
dc.contributor.googleauthor | Park, Dong Won | - |
dc.contributor.googleauthor | Seo, Ji-Young | - |
dc.contributor.googleauthor | Moon, Ji-Yong | - |
dc.contributor.googleauthor | Kim, Tae Hyung | - |
dc.contributor.googleauthor | Sohn, Jang Won | - |
dc.contributor.googleauthor | Shin, Dong Ho | - |
dc.contributor.googleauthor | Yoon, Ho Joo | - |
dc.contributor.googleauthor | Park, Sung Soo | - |
dc.contributor.googleauthor | Kim, Sang-Heon | - |
dc.relation.code | 2015002614 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | sangheonkim | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.