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dc.contributor.authorKUTZNER, ARNE HOLGER-
dc.date.accessioned2017-09-13T07:28:56Z-
dc.date.available2017-09-13T07:28:56Z-
dc.date.issued2015-11-
dc.identifier.citationGENOMICS, v. 106, NO 5, Page. 278-285en_US
dc.identifier.issn0888-7543-
dc.identifier.issn1089-8646-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0888754315300185-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/29115-
dc.description.abstractFAM72 is a novel neuronal progenitor cell (NPC) self-renewal supporting protein expressed under physiological conditions at low levels in other tissues. Accumulating data indicate the potential pivotal tumourigenic effects of FAM72. Our in silico human genome-wide analysis (GWA) revealed that the FAM72 gene family consists of four human-specific paralogous members, all of which are located on chromosome (chr) 1. Unique asymmetric FAM72 segmental gene duplications are most likely to have occurred in conjunction with the paired genomic neighbour SRGAP2 (SLIT-ROBO Rho GTPase activating protein), as both genes have four paralogues in humans but only one vertebra-emerging orthologue in all other species. No species with two or three FAM72/SRGAP2 gene pairs could be identified, and the four exclusively human-defining ohnologues, with different mutation patterns in Homo neanderthalensis and Denisova hominin, may remain under epigenetic control through long non-coding (lnc) RNAs. (C) 2015 Published by Elsevier Inc.en_US
dc.description.sponsorshipThis study was supported by Hanyang University. We thank the people at the Max Planck Institute for Evolutionary Anthropology (eva.mpg.de) for providing the Neanderthal and Denisova genome data.en_US
dc.language.isoenen_US
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEen_US
dc.subjectFAM72en_US
dc.subjectneuronen_US
dc.subjectcanceren_US
dc.subjecthomoen_US
dc.subjectp17en_US
dc.titleAll-or-(N)One - an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene locien_US
dc.typeArticleen_US
dc.relation.no5-
dc.relation.volume106-
dc.identifier.doi10.1016/j.ygeno.2015.07.003-
dc.relation.page278-285-
dc.relation.journalGENOMICS-
dc.contributor.googleauthorKutzner, Arne-
dc.contributor.googleauthorPramanik, Subrata-
dc.contributor.googleauthorKim, Pok-Son-
dc.contributor.googleauthorHeese, Klaus-
dc.relation.code2015003606-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDEPARTMENT OF INFORMATION SYSTEMS-
dc.identifier.pidkutzner-
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COLLEGE OF ENGINEERING[S](공과대학) > INFORMATION SYSTEMS(정보시스템학과) > Articles
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