Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 고인송 | - |
dc.date.accessioned | 2017-09-13T06:03:21Z | - |
dc.date.available | 2017-09-13T06:03:21Z | - |
dc.date.issued | 2015-11 | - |
dc.identifier.citation | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v. 40, NO 3, Page. 692-697 | en_US |
dc.identifier.issn | 1382-6689 | - |
dc.identifier.issn | 1872-7077 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S1382668915300776?via%3Dihub | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/29108 | - |
dc.description.abstract | Organic anion-transporting polypeptide (OATP; gene symbol, SLCO) transporters are generally involved in the uptake of multiple drugs and their metabolites at most epithelial barriers. The pattern of single-nucleotide polymorphisms (SNPs) in these transporters may be determinants of interindividual variability in drug disposition and response. The objective of this study was to define the distribution of SNPs of three SLCO genes, SLCO1B1, SLCO1B3, and SLCO2B1, in a Korean population and other ethnic groups. The study was screened using the Illumina GoldenGate assay for genomic DNA from 450 interethnic subjects, including 11 pharmacogenetic core variants and 76 HapMap tagging SNPs. The genotype distribution of the Korean population was similar to East Asian populations, but significantly different from African American and European American cohorts. These interethnic differences will be useful information for prospective studies, including genetic association and pharmacogenetic studies of drug metabolism by SLCO families. (C) 2015 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This research was supported by a grant (08171MFDS505) from the Ministry of Food and Drug Safety in 2012. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | Organic anion-transporting peptide genes | en_US |
dc.subject | Ethnic diversity | en_US |
dc.subject | Pharmacogenetics | en_US |
dc.title | Comparison of genetic variations of the SLCO1B1, SLCO1B3, and SLCO2B1 genes among five ethnic groups | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 40 | - |
dc.identifier.doi | 10.1016/j.etap.2015.08.033 | - |
dc.relation.page | 692-697 | - |
dc.relation.journal | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | - |
dc.contributor.googleauthor | Namgoong, Suhg | - |
dc.contributor.googleauthor | Cheong, Hyun Sub | - |
dc.contributor.googleauthor | Kim, Ji On | - |
dc.contributor.googleauthor | Kim, Lyoung Hyo | - |
dc.contributor.googleauthor | Na, Han Sung | - |
dc.contributor.googleauthor | Koh, In Song | - |
dc.contributor.googleauthor | Chung, Myeon Woo | - |
dc.contributor.googleauthor | Shin, Hyoung Doo | - |
dc.relation.code | 2015001453 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | insong | - |
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