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dc.contributor.author장동표-
dc.date.accessioned2017-09-12T02:03:24Z-
dc.date.available2017-09-12T02:03:24Z-
dc.date.issued2015-11-
dc.identifier.citationMICROVASCULAR RESEARCH, v. 102, Page. 46-53en_US
dc.identifier.issn0026-2862-
dc.identifier.issn1095-9319-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0026286215300182?via%3Dihub-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/29079-
dc.description.abstractThe aim of this study was to investigate how the interrelationships between low-frequency oscillations (LFOs) in the cerebral and systemic cardiovascular hemodynamic systems change with aging and systemic hemodynamic perturbation. Seventeen young adult (28.4 +/- 3.5 years) and seventeen elderly subjects (69.4 +/- 8.7 years) underwent continuous measurements of arterial blood pressure (ABP), heart rate (HR), and cerebral oxygenation (oxy-hemoglobin, deoxy-hemoglobin, and total hemoglobin) using near-infrared spectroscopy. The LFOs were subdivided into three frequency intervals (FI-1: 0.01-0.02 Hz, FI-2: 0.02-0.06 Hz, and FI-3: 0.06-0.15 Hz) via spectral analysis based on continuous wavelet transform. The amplitudes of the LFOs at these FIs were calculated to examine the effects of aging and head-up tilt (HUT) on cerebral and cardiovascular hemodynamics. Granger causality (GC) was used for analyzing the causal relationships between the LFOs observed in ABP, oxyhemoglobin, and HR. The amplitudes of the LFOs were generally higher in young adults than in the elderly and increased significantly only in the younger subjects after HUT. GCs in FI-3 oscillations were significantly higher in young subjects compared to older participants in the HUT state. These results indicate that aging dampens systemic and cerebral hemodynamic regulatory mechanisms, and the interrelationships between systemic and cerebral hemodynamics become weaker with age. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by the ICT R&D program of MSIP/IITP [10045452, Development of Multimodal Brain-Machine Interface System Based on User Intent Recognition], and the National Research Foundation of Korea (NRF) grant funded by the Ministry of Education, Science and Technology (2013R1A2A2A04014987).en_US
dc.language.isoenen_US
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEen_US
dc.subjectAgeen_US
dc.subjectGranger causalityen_US
dc.subjectHead-up tilten_US
dc.subjectLow-frequency oscillationen_US
dc.subjectWavelet transformen_US
dc.titleLow-frequency oscillations in cerebrovascular and cardiovascular hemodynamics: Their interrelationships and the effect of ageen_US
dc.typeArticleen_US
dc.relation.volume102-
dc.identifier.doi10.1016/j.mvr.2015.08.004-
dc.relation.page46-53-
dc.relation.journalMICROVASCULAR RESEARCH-
dc.contributor.googleauthorSong, Soohwa-
dc.contributor.googleauthorKim, Dohyun-
dc.contributor.googleauthorJang, Dong Pyo-
dc.contributor.googleauthorLee, Jongshill-
dc.contributor.googleauthorLee, Hyon-
dc.contributor.googleauthorLee, Kyoung-Min-
dc.contributor.googleauthorKim, In Young-
dc.relation.code2015003341-
dc.sector.campusS-
dc.sector.daehakGraduate School of Biomedical Science & Engineering[S]-
dc.identifier.piddongpjang-
Appears in Collections:
GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > ETC
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