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dc.contributor.author김진웅-
dc.date.accessioned2017-09-12T01:21:21Z-
dc.date.available2017-09-12T01:21:21Z-
dc.date.issued2015-11-
dc.identifier.citationCOLLOIDS AND SURFACES B-BIOINTERFACES, v. 135, Page. 324-331en_US
dc.identifier.issn0927-7765-
dc.identifier.issn1873-4367-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0927776515300953?via%3Dihub-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/29069-
dc.description.abstractWe describe a promising non-invasive transdermal delivery system comprising block copolymer composite micelles that contained a phase-change material (PCM), photothermal Au nanoparticles (AuNPs), and hydrophobic drugs in the core. To minimize cell toxicity, we developed block copolymer micelles with a poly(epsilon-caprolactone) (PCL) biodegradable core and a hyperbranched polyglycol (hbPG) shell. The hbPG block formed micelles at a low-molecular-weight fraction of a low-molecular-weight block copolymer. The composite micelles showed excellent biocompatibility with cell viability at high concentrations. Visible light irradiation (lambda = 520 nm) of the composite micelles induced the photothermal effects of the AuNPs and melting of the PCM (lauric acid); hence, the drugs were released along with the PCM liquid. The release rate was controlled by the light intensity. Based on in vitro and in vivo skin penetration studies, the skin permeability of the drug remarkably improved under mild light irradiation (18 J/cm(2)) that was much lower than the dose that causes skin damage. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by a National Research Foundation (NRF) grant that was funded by the Korean Government (MEST) through NRF-2012R1A1A2008403.en_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectTransdermal deliveryen_US
dc.subjectPhotothermal effecten_US
dc.subjectPhase changing materialsen_US
dc.subjectAu nanoparticlesen_US
dc.subjectBlock copolymer micelleen_US
dc.titleCombination of nanoparticles with photothermal effects and phase-change material enhances the non-invasive transdermal delivery of drugsen_US
dc.typeArticleen_US
dc.relation.no0-
dc.relation.volume135-
dc.identifier.doi10.1016/j.colsurfb.2015.07.061-
dc.relation.page324-331-
dc.relation.journalCOLLOIDS AND SURFACES B-BIOINTERFACES-
dc.contributor.googleauthorKim, Yong-Jin-
dc.contributor.googleauthorKim, Bongsoo-
dc.contributor.googleauthorKim, Jin Woong-
dc.contributor.googleauthorNam, Gaewon-
dc.contributor.googleauthorJang, Hyon-Seok-
dc.contributor.googleauthorKang, Sun-woong-
dc.contributor.googleauthorJeong, Unyong-
dc.relation.code2015001660-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidkjwoong-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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