Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2017-09-11T05:46:07Z | - |
dc.date.available | 2017-09-11T05:46:07Z | - |
dc.date.issued | 2015-11 | - |
dc.identifier.citation | AUTOIMMUNITY, v. 48, NO 7, Page. 445-452 | en_US |
dc.identifier.issn | 0891-6934 | - |
dc.identifier.issn | 1607-842X | - |
dc.identifier.uri | http://www.tandfonline.com/doi/full/10.3109/08916934.2015.1045582 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/29033 | - |
dc.description.abstract | Objective: The aim of this study was to explore whether the FOXP3-3279 A/C polymorphism and (GT)n microsatellite polymorphisms are associated with susceptibility to autoimmune diseases. Methods: A meta-analysis was conducted on the associations between the FOXP3 -3279 A/C polymorphism and (GT)15 and (GT)16 polymorphisms and autoimmune diseases. Results: Twenty-two comparative studies with a total of 7962 patients and 7453 controls were included in the meta-analysis. Meta-analysis revealed an association between autoimmune disease and the FOXP3 -3279 AA + AC genotype (OR = 1.480, 95% CI = 1.263-1.614, p ˂ 1.0 × 10), and stratification by ethnicity indicated a significant association between the FOXP3 -3279 AA + AC genotype and autoimmune diseases in Asians (OR = 1.416, 95% CI = 1.225-1.637, p = 2.5 × 10) and non-Caucasians (OR = 1.432, 95% CI = 1.245-1.647, p = 7.5 × 10). In addition, corrected p values for multiple testing remained significant. Meta-analysis revealed no association between autoimmune disease and the FOXP3 (GT)15 allele (OR = 1.051, 95% CI = 0.933-1.183, p = 0.413). Similarly, the FOXP3 (GT)16 allele showed no associations with autoimmune disease. Conclusions: This meta-analysis indicates that the FOXP3 -3279 A/C polymorphism is associated with susceptibility to autoimmune disease in Asians and non-Caucasians. © 2015 Informa UK Ltd. | en_US |
dc.description.sponsorship | This study was supported in part by a grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI13C2124). | en_US |
dc.language.iso | en | en_US |
dc.publisher | INFORMA HEALTHCARE | en_US |
dc.subject | Autoimmune diseases | en_US |
dc.subject | FOXP3 | en_US |
dc.subject | polymorphism | en_US |
dc.subject | meta-analysis | en_US |
dc.title | Association between FOXP3 polymorphisms and susceptibility to autoimmune diseases: A meta-analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 7 | - |
dc.relation.volume | 48 | - |
dc.identifier.doi | 10.3109/08916934.2015.1045582 | - |
dc.relation.page | 445-452 | - |
dc.relation.journal | AUTOIMMUNITY | - |
dc.contributor.googleauthor | Lee, Min-Gu | - |
dc.contributor.googleauthor | Bae, Sang-Cheol | - |
dc.contributor.googleauthor | Lee, Young Ho | - |
dc.relation.code | 2015011352 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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