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Association between FOXP3 polymorphisms and susceptibility to autoimmune diseases: A meta-analysis

Title
Association between FOXP3 polymorphisms and susceptibility to autoimmune diseases: A meta-analysis
Author
배상철
Keywords
Autoimmune diseases; FOXP3; polymorphism; meta-analysis
Issue Date
2015-11
Publisher
INFORMA HEALTHCARE
Citation
AUTOIMMUNITY, v. 48, NO 7, Page. 445-452
Abstract
Objective: The aim of this study was to explore whether the FOXP3-3279 A/C polymorphism and (GT)n microsatellite polymorphisms are associated with susceptibility to autoimmune diseases. Methods: A meta-analysis was conducted on the associations between the FOXP3 -3279 A/C polymorphism and (GT)15 and (GT)16 polymorphisms and autoimmune diseases. Results: Twenty-two comparative studies with a total of 7962 patients and 7453 controls were included in the meta-analysis. Meta-analysis revealed an association between autoimmune disease and the FOXP3 -3279 AA + AC genotype (OR = 1.480, 95% CI = 1.263-1.614, p ˂ 1.0 × 10), and stratification by ethnicity indicated a significant association between the FOXP3 -3279 AA + AC genotype and autoimmune diseases in Asians (OR = 1.416, 95% CI = 1.225-1.637, p = 2.5 × 10) and non-Caucasians (OR = 1.432, 95% CI = 1.245-1.647, p = 7.5 × 10). In addition, corrected p values for multiple testing remained significant. Meta-analysis revealed no association between autoimmune disease and the FOXP3 (GT)15 allele (OR = 1.051, 95% CI = 0.933-1.183, p = 0.413). Similarly, the FOXP3 (GT)16 allele showed no associations with autoimmune disease. Conclusions: This meta-analysis indicates that the FOXP3 -3279 A/C polymorphism is associated with susceptibility to autoimmune disease in Asians and non-Caucasians. © 2015 Informa UK Ltd.
URI
http://www.tandfonline.com/doi/full/10.3109/08916934.2015.1045582http://hdl.handle.net/20.500.11754/29033
ISSN
0891-6934; 1607-842X
DOI
10.3109/08916934.2015.1045582
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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