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dc.contributor.author김철근-
dc.date.accessioned2017-09-11T05:14:29Z-
dc.date.available2017-09-11T05:14:29Z-
dc.date.issued2015-11-
dc.identifier.citationGENES & GENOMICS, v. 37, NO 12, Page. 1073-1079en_US
dc.identifier.issn1976-9571-
dc.identifier.issn2092-9293-
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs13258-015-0364-4-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/29031-
dc.description.abstractIn the present study, necrosis inhibitor-5 (NecroX-5), a novel Cyclopentylamino carboxymethylthiazolylindole (NecroX) series compound was investigated for its protective role against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in a zebrafish model of Parkinson's disease (PD). MPTP-induced locomotor behavior was measured in zebrafish larvae and the protein expression level of tyrosine hydroxylase (TH) was estimated in zebrafish larva homogenates. MPTP (15 mu M) induced a significant (p ˂ 0.05) impairment in zebrafish larvae locomotor behavior. Treatment with NecroX-5 at various doses (3.75, 7.5 and 15 mu M) significantly and dose dependently (p ˂ 0.05) restored MPTP-induced locomotor impairments in zebrafish larvae. Further, NecroX-5 significantly attenuated the MPTP-induced decrease in zebrafish TH protein expression levels. The effects observed by NecroX-5 were almost two fold higher when compared with the antioxidant, minocycline. In conclusion, the neuroprotective activity exhibited by NecroX-5 by attenuating MPTP-induced locomotor impairments and dopaminergic TH expression in zebrafish warrants further development of NecroX-5 as a novel neuroprotectant in the treatment of neurodegenerative disorders including PD.en_US
dc.description.sponsorshipThe National Research Foundation of Korea (NRF-2010-0012391) supported this work.en_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.subjectNecroXen_US
dc.subjectOxidative stressen_US
dc.subjectTyrosine hydroxylaseen_US
dc.subjectZebrafishen_US
dc.subjectParkinson's diseaseen_US
dc.titleNecrosis inhibitor-5 (NecroX-5), attenuates MPTP-induced motor deficits in a zebrafish model of Parkinson's diseaseen_US
dc.typeArticleen_US
dc.relation.no12-
dc.relation.volume37-
dc.identifier.doi10.1007/s13258-015-0364-4-
dc.relation.page1073-1079-
dc.relation.journalGENES & GENOMICS-
dc.contributor.googleauthorLiu, Jun-Cheng-
dc.contributor.googleauthorKoppula, Sushruta-
dc.contributor.googleauthorHuh, Se-Jong-
dc.contributor.googleauthorPark, Pyo-Jam-
dc.contributor.googleauthorKim, Chul-Geun-
dc.contributor.googleauthorLee, Chang-Joong-
dc.contributor.googleauthorKim, Chan-Gil-
dc.relation.code2015010102-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidcgkim-
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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