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dc.contributor.author이영복-
dc.date.accessioned2017-09-08T00:13:41Z-
dc.date.available2017-09-08T00:13:41Z-
dc.date.issued2015-11-
dc.identifier.citationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v. 63, NO 47, Page. 10227-10233en_US
dc.identifier.issn0021-8561-
dc.identifier.issn1520-5118-
dc.identifier.urihttp://pubs.acs.org/doi/10.1021/acs.jafc.5b03730-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/28960-
dc.description.abstractIn this study, we investigated potentially probiotic Bacillus licheniformis strains isolated from traditional Korean food sources for ability to enhance longevity using the nematode Caenorhabditis elegans as a simple in vivo animal model. We first investigated whether B. licheniformis strains were capable of modulating the lifespan of C. elegans. Among the tested strains, preconditioning with four B. licheniformis strains significantly enhanced the longevity of C. elegans. Unexpectedly, plate counting and transmission electron microscopy (TEM) results indicated that B. licheniformis strains were not more highly attached to the C. elegans intestine compared with Escherichia coli OP50 or Lactobacillus rhamnosus GG controls. In addition, qRT-PCR and an aging assay with mutant worms showed that the conditioning of B. licheniformis strain 141 directly influenced genes associated with serotonin signaling in nematodes, including tph-1 (tryptophan hydroxylase), bas-1 (serotonin- and dopamine-synthetic aromatic amino acid decarboxylase), mod-1 (serotonin-gated chloride channel), ser-1, and ser-7 (serotonin receptors) during C. elegans aging. Our findings suggest that B. licheniformis strain 141, which is isolated from traditional Korean foods, is a probiotic generally recognized as safe (GRAS) strain that enhances the lifespan of C. elegans via host serotonin signaling.en_US
dc.description.sponsorshipThis research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2014R1A1A1006872) and by the High Value-Added Food Technology Development Program of the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry, and Fisheries (iPET), Ministry for Food, Agriculture, Forestry, and Fisheries of the Republic of Korea (111137-03-3-SB010).en_US
dc.language.isoenen_US
dc.publisherAMER CHEMICAL SOCen_US
dc.subjectCaenorhabditis elegansen_US
dc.subjectBacillus licheniformisen_US
dc.subjectserotonin signalingen_US
dc.subjectantiagingen_US
dc.subjectKorean traditional foodsen_US
dc.titleBacillus licheniformis Isolated from Traditional Korean Food Resources Enhances the Longevity of Caenorhabditis elegans through Serotonin Signalingen_US
dc.typeArticleen_US
dc.relation.no47-
dc.relation.volume63-
dc.identifier.doi10.1021/acs.jafc.5b03730-
dc.relation.page10227-10233-
dc.relation.journalJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY-
dc.contributor.googleauthorPark, Mi Ri-
dc.contributor.googleauthorOh, Sangnam-
dc.contributor.googleauthorSon, Seok Jun-
dc.contributor.googleauthorPark, Dong-June-
dc.contributor.googleauthorOh, Sejong-
dc.contributor.googleauthorKim, Sae Hun-
dc.contributor.googleauthorJeong, Do-Youn-
dc.contributor.googleauthorOh, Nam Su-
dc.contributor.googleauthorLee, Youngbok-
dc.contributor.googleauthorSong, Minho-
dc.relation.code2015002248-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidyblee-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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