Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희진 | - |
dc.date.accessioned | 2017-08-23T02:19:10Z | - |
dc.date.available | 2017-08-23T02:19:10Z | - |
dc.date.issued | 2015-11 | - |
dc.identifier.citation | DEMENTIA AND NEUROCOGNITIVE DISORDERS, v. 14, Page. 143-148 | en_US |
dc.identifier.issn | 1738-1495 | - |
dc.identifier.issn | 2384-0757 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.12779/dnd.2015.14.4.143 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/28732 | - |
dc.description.abstract | Background and Purpose Subjective cognitive decline has been proposed as a potential indicator of the preclinical state of Alzheimer's disease (AD). The results of the studies of cortical atrophy on brain MRIs in subjects with subjective cognitive decline are inconsistent across the literatures. We investigated whether subjects with subjective cognitive decline had less gray matter volume compared to controls without subjective cognitive decline as per brain MRI. Methods Thirty-six subjects with subjective cognitive decline and thirty-three controls without subjective cognitive decline were recruited retrospectively from among the patients who had visited the department of neurology at Inha University Hospital between January 2008 and December 2010. All subjects had undergone a brain MRI scan including 3D T1-weighted spoiled gradient recalled echo imaging. We used voxel-based morphometry (VBM) to examine gray matter volumes between the two groups, after controlling for age, sex, education, and total intracranial volumes (TIV). Results There were no significant differences in age, gender, education, and TIV between the two groups. In comparison to controls without subjective cognitive decline, subjects with subjective cognitive decline showed gray matter atrophy in the left superior and medial frontal gyri, left superior and inferior parietal lobules, and right precuneus and insular in the VBM analysis. Conclusions Individuals with subjective cognitive decline encountered in clinical settings have greater similarity to an AD gray matter atrophy pattern compared with cognitively normal individuals without subjective cognitive decline. | en_US |
dc.description.sponsorship | This study was supported by the Original Technology Research Program for Brain Science through the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2014M3C7A1064752). | en_US |
dc.language.iso | en | en_US |
dc.publisher | 대한치매학회 | en_US |
dc.subject | subjective cognitive decline | en_US |
dc.subject | voxel based morphometry | en_US |
dc.subject | gray matter | en_US |
dc.subject | atrophy | en_US |
dc.title | Reduced Gray Matter Volume in Subjective Cognitive Decline: A Voxel-Based Morphometric Study | en_US |
dc.type | Article | en_US |
dc.relation.volume | 14 | - |
dc.identifier.doi | 10.12779/dnd.2015.14.4.143 | - |
dc.relation.page | 143-148 | - |
dc.relation.journal | DEMENTIA AND NEUROCOGNITIVE DISORDERS | - |
dc.contributor.googleauthor | Choi, Yoonjae | - |
dc.contributor.googleauthor | Yoon, Byung-Nam | - |
dc.contributor.googleauthor | Choi, Seong Hye | - |
dc.contributor.googleauthor | Lim, Myung Kwan | - |
dc.contributor.googleauthor | Kim, Hee-Jin | - |
dc.contributor.googleauthor | Yang, Dong-Won | - |
dc.relation.code | 2012215947 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hyumcbrain | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.