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dc.contributor.author이은규-
dc.date.accessioned2017-08-21T07:54:13Z-
dc.date.available2017-08-21T07:54:13Z-
dc.date.issued2015-11-
dc.identifier.citationBIOTECHNOLOGY JOURNAL, v. 10, NO 11, Page. 1682-1688en_US
dc.identifier.issn1860-6768-
dc.identifier.issn1860-7314-
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1002/biot.201500092/abstract;jsessionid=772A5F40919BC495911FAFCFE3A284AD.f04t04-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/28660-
dc.description.abstractMicrofabricated systems equipped with 3D cell culture devices and in-situ cellular biosensing tools can be a powerful bionanotechnology platform to investigate a variety of biomedical applications. Various construction substrates such as plastics, glass, and paper are used for microstructures. When selecting a construction substrate, a key consideration is a porous microenvironment that allows for spheroid growth and mimics the extracellular matrix (ECM) of cell aggregates. Various bio-functionalized hydrogels are ideal candidates that mimic the natural ECM for 3D cell culture. When selecting an optimal and appropriate microfabrication method, both the intended use of the system and the characteristics and restrictions of the target cells should be carefully considered. For highly sensitive and near-cell surface detection of excreted cellular compounds, SERS-based microsystems capable of dual modal imaging have the potential to be powerful tools; however, the development of optical reporters and nanoprobes remains a key challenge. We expect that the microsystems capable of both 3D cell culture and cellular response monitoring would serve as excellent tools to provide fundamental cellular behavior information for various biomedical applications such as metastasis, wound healing, high throughput screening, tissue engineering, regenerative medicine, and drug discovery and development.en_US
dc.description.sponsorshipThis work was supported by the Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Science, ICT & Future Planning (No. 2008-0061891). We thank Ms. Eun Won Lee for her help during preparation of the manuscript.en_US
dc.language.isoenen_US
dc.publisherWILEY-V C H VERLAG GMBHen_US
dc.subject3D cell culture microsystemen_US
dc.subjectBionanotechnologyen_US
dc.subjectCellular biosensingen_US
dc.subjectFunctionalized hydrogelsen_US
dc.subjectSpheroid cell cultureen_US
dc.titleMicro 3D cell culture systems for cellular behavior studies: Culture matrices, devices, substrates, and in-situ sensing methodsen_US
dc.typeArticleen_US
dc.relation.no11-
dc.relation.volume10-
dc.identifier.doi10.1002/biot.201500092-
dc.relation.page1682-1688-
dc.relation.journalBIOTECHNOLOGY JOURNAL-
dc.contributor.googleauthorChoi, Jonghoon-
dc.contributor.googleauthorLee, Eun Kyu-
dc.contributor.googleauthorChoo, Jaebum-
dc.contributor.googleauthorYuh, Junhan-
dc.contributor.googleauthorHong, Jong Wook-
dc.relation.code2015008337-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pideklee-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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