Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김종희 | - |
dc.date.accessioned | 2017-08-11T05:43:15Z | - |
dc.date.available | 2017-08-11T05:43:15Z | - |
dc.date.issued | 2015-10 | - |
dc.identifier.citation | EXPERIMENTAL GERONTOLOGY, v. 70, Page. 163-173 | en_US |
dc.identifier.issn | 0531-5565 | - |
dc.identifier.issn | 1873-6815 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0531556515300231?via%3Dihub | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/28505 | - |
dc.description.abstract | Fibrosis of the aging heart impedes cardiac function and increases the risk of arrhythmias and heart disease. Previously, we demonstrated that exercise-induced reduction of collagen I in the aging heart was linked to a suppression of oxidative stress and transforming growth factor-beta (TGF-beta). The renin-angiotensin II system (RAS) increases oxidative stress via NADPH oxidase-2 (Nox2) and thus elevates TGF-beta and collagen accumulation. Therefore, we tested the hypothesis that exercise training would alleviate age-related upregulation of the angiotensin II receptor I (AT1R) and NADPH oxidase-2 (Nox2), concomitant with suppression of TGF-beta and fibrosis. Young (3 months, n = 20) and old (31 months, n = 20) Fischer 344 x Brown Norway F1 (FBNF1) hybrid rats were assigned into sedentary and exercise groups, with exercise training rats training on a treadmill 45 min/day, 5 days/week for the next 12 weeks. Exercise training mitigated age-related upregulation of AT1R, Nox2 activity, and Nox2 subunits gp91phox and p47phox. Exercise training also attenuated TGF-beta positive staining and downstream effectors of fibrosis in the aging heart: connective tissue growth factor, phosphorylation of Smad2 at Ser423, myofibroblast proliferation, and collagen I-positive staining. Our results are consistent with the hypothesis that exercise training protects against age-dependent cardiac fibrosis by suppressing AT1R and Nox2 as part of a RAS-Nox2-TGF-beta pathway. (C) 2015 Elsevier Inc. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by American Heart Association Grant-in-Aid 0555064Y and 0855158F (JML) and the Sydney and J. L. Huffines Institute for Sports Medicine (JML, YL). | en_US |
dc.language.iso | en | en_US |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en_US |
dc.subject | Aging | en_US |
dc.subject | Heart | en_US |
dc.subject | Angiotensin II receptor 1 | en_US |
dc.subject | NADPH oxidase | en_US |
dc.subject | TGF-beta | en_US |
dc.title | Exercise training attenuates age-dependent elevation of angiotensin II type 1 receptor and Nox2 signaling in the rat heart | en_US |
dc.type | Article | en_US |
dc.relation.volume | 70 | - |
dc.identifier.doi | 10.1016/j.exger.2015.07.016 | - |
dc.relation.page | 163-173 | - |
dc.relation.journal | EXPERIMENTAL GERONTOLOGY | - |
dc.contributor.googleauthor | Lee, Yang | - |
dc.contributor.googleauthor | Kwak, Hyo-Bum | - |
dc.contributor.googleauthor | Hord, Jeff | - |
dc.contributor.googleauthor | Kim, Jong-Hee | - |
dc.contributor.googleauthor | Lawler, John M. | - |
dc.relation.code | 2015000952 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ART AND PHYSICAL EDUCATION[S] | - |
dc.sector.department | DEPARTMENT OF PHYSICAL EDUCATION | - |
dc.identifier.pid | carachel07 | - |
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