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dc.contributor.author박용순-
dc.date.accessioned2017-08-09T06:01:48Z-
dc.date.available2017-08-09T06:01:48Z-
dc.date.issued2015-10-
dc.identifier.citationNUTRITION, v. 31, NO 11-12, Page. 1362-1367en_US
dc.identifier.issn0899-9007-
dc.identifier.issn1873-1244-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0899900715002440?via%3Dihub-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/28414-
dc.description.abstractObjective: The nutritional status of patients with amyotrophic lateral sclerosis (ALS) has been shown to be associated with mortality. However, there have not been, to our knowledge, any studies on the association between nutritional status and disease severity. The present study investigated the hypothesis that nutritional status was negatively associated with disease severity using the ALS functional rating scale (ALSFRS-R). Methods: One hundred ninety-three Korean ALS patients were divided into tertiles based on their ALSFRS-R score. Dietary intake was measured using 24 h recall and nutritional status was determined by body mass index (BMI) and geriatric nutritional risk index (GNRI). Results: BMI and GNRI were significantly lower in patients in the lowest tertile of ALSFRS-R. BMI and GNRI also correlated with ALSFRS-R score, bulbar score, albumin levels, total lymphocyte count, and total daily energy expenditure. Intakes of energy and most nutrients were significantly lower in patients in the lowest tertiles of ALSFRS-R, but significances disappeared after adjusting for energy intake. Intakes of vegetables, grains, seasonings, and oils were also significantly lower in patients in the lowest tertile of ALSFRS-R. In addition, patients in the lowest tertile of ALSFRS-R were significantly younger at disease onset, had a longer duration of ALS, less regular exercise, and less sun exposure. Conclusion: Nutritional status, as assessed by BMI and GNRI, was negatively associated with disease severity using ALSFRS-R. The present study suggested that intake of nutrients decreases with disease progression in ALS patients. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by the Korea Research Foundation (2012 R1 A2040553) and the Center for Women in Science, Engineering and Technology (WISET) Grant (KW-2014-PPD-0056) funded by the Ministry of Science, ICT & Future Planning of Korea (MSIP).en_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.subjectAmyotrophic lateral sclerosisen_US
dc.subjectRevised ALS functional rating scaleen_US
dc.subjectBody mass indexen_US
dc.subjectGeriatric nutritional risk indexen_US
dc.subjectDietary intakeen_US
dc.titleAssociation between nutritional status and disease severity using the amyotrophic lateral sclerosis (ALS) functional rating scale in ALS patientsen_US
dc.typeArticleen_US
dc.relation.no11-12-
dc.relation.volume31-
dc.identifier.doi10.1016/j.nut.2015.05.025-
dc.relation.page1362-1367-
dc.relation.journalNUTRITION-
dc.contributor.googleauthorPark, Yongsoon-
dc.contributor.googleauthorPark, Jinhee-
dc.contributor.googleauthorKim, Yeonsun-
dc.contributor.googleauthorBaek, Heejoon-
dc.contributor.googleauthorKim, Seung Hyun-
dc.relation.code2015003446-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF HUMAN ECOLOGY[S]-
dc.sector.departmentDEPARTMENT OF FOOD & NUTRITION-
dc.identifier.pidyongsoon-
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COLLEGE OF HUMAN ECOLOGY[S](생활과학대학) > FOOD & NUTRITION(식품영양학과) > Articles
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