238 0

Nigrostriatal dopamine-independent resting-state functional networks in Parkinson's disease

Title
Nigrostriatal dopamine-independent resting-state functional networks in Parkinson's disease
Author
이종민
Keywords
Resting-state functional connectivity; Parkinson's disease; Drug induced parkinsonism; Dopamine independent network
Issue Date
2015-10
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
NEUROIMAGE, v. 119, Page. 296-304
Abstract
As an indicator of synchronous neural activity, resting-state functional networks are influenced by neuropathological and neurochemical changes in degenerative diseases. To further advance understanding about neurochemical and neuropathological basis for resting-state functional maps, we performed a comparative analysis of resting-state functional connectivity in patients with Parkinson's disease (PD) and drug induced parkinsonism (DIP). Resting-state neuroimaging data were analyzed with a seed-based approach to investigate striatocortical functional connectivity and cortical functional connectivity within the default mode network, executive control network, and the dorsal attention network. The striatal subregions were divided into the more or less affected sides in terms of dopamine transporter uptake. Compared with DIP, PD exhibited an increased cerebellar connectivity from the more affected side of the caudate and the less affected sides of the anterior and the posterior putamen. Additionally, PD showed increased functional connectivity in the anterior prefrontal areas from the more affected side of the anterior putamen and from the less affected side of the posterior putamen. However, PD exhibited decreased cortical functional connectivity from the posterior cingulate cortex in the left temporal area. Finally, DIP patients showed decreased cortical functional connectivity from the dorsolateral prefrontal cortex in frontal and parietal areas compared with PD patients. In summary, the present study demonstrates that PD patients exhibited a unique resting state functional connectivity that may be associated with PD-related pathological changes beyond the dopaminergic system, whereas DIP patients showed altered functional connectivity within executive control network. (C) 2015 Published by Elsevier Inc.
URI
http://www.sciencedirect.com/science/article/pii/S1053811915005820?via%3Dihubhttp://hdl.handle.net/20.500.11754/28390
ISSN
1053-8119; 1095-9572
DOI
10.1016/j.neuroimage.2015.06.077
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE