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Association of Body Fat Percentage and Waist-hip Ratio With Brain Cortical Thickness A Study Among 1777 Cognitively Normal Subjects

Title
Association of Body Fat Percentage and Waist-hip Ratio With Brain Cortical Thickness A Study Among 1777 Cognitively Normal Subjects
Author
이종민
Keywords
cortical thickness; body fat percentage; waist hip ratio; MRI; surface-based morphometric analysis
Issue Date
2015-10
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
ALZHEIMER DISEASE & ASSOCIATED DISORDERS, v. 29, NO 4, Page. 279-286
Abstract
Background:Increasing evidence has emerged that there is a link between body weight and the risk of developing dementia. However, the relationship between adiposity and brain structure has not yet been fully elucidated. We aimed to evaluate the association of body fat composition with cortical thickness in cognitively normal subjects.Methods:In total, 1777 (887 men and 890 women) cognitively normal subjects, aged 45 years or older, were recruited from the Health Promotion Center in South Korea. Medical records including 3-dimensional magnetic resonance imaging, body fat percentage, waist-hip ratio (WHR), and other factors were reviewed.Results:In men, the percentage of fat was positively associated with cortical thickness and the highest WHR group showed significantly decreased cortical thickness compared with the reference group. WHR showed an inverted U-shaped association with total cortical thickness and frontal lobe thickness in men. Among women, there was no significant association.Conclusions:Our findings suggest that in men, body fat is positively associated with cortical thickness, whereas abdominal fat is negatively associated with cortical thickness.
URI
http://pt.wkhealth.com/pt/re/lwwgateway/landingpage.htm;jsessionid=ZJXYDqVLvLNBysGy6hyQKQGvF776YhyfLTsJnfsXh4qxcxKQyPn1!721960586!181195628!8091!-1?sid=WKPTLP:landingpage&an=00002093-201510000-00002http://hdl.handle.net/20.500.11754/28389
ISSN
0893-0341
DOI
10.1097/WAD.0000000000000079
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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