Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 노영석 | - |
dc.date.accessioned | 2017-08-04T07:18:10Z | - |
dc.date.available | 2017-08-04T07:18:10Z | - |
dc.date.issued | 2015-10 | - |
dc.identifier.citation | MOLECULAR AND CELLULAR ENDOCRINOLOGY, v. 414, Page. 64-72 | en_US |
dc.identifier.issn | 0303-7207 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S030372071530023X?via%3Dihub | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/28316 | - |
dc.description.abstract | Effective treatment of diabetic neuropathy (DN) remains unsolved. We serendipitously observed dramatic relief of pain in several patients with painful DN receiving granulocyte-colony stimulating factor (G-CSF). The aim of this study was to determine if G-CSF could treat DN in an animal model and to ascertain its mechanism of action. In a rodent model of DN, G-CSF dramatically recovered nerve function, retarded histological nerve changes and increased the expression of neurotrophic factors within nerve. A sex-mismatched bone marrow transplantation (BMT) study revealed that G-CSF treatment increased the abundance of bone marrow (BM)-derived cells in nerves damaged by DN. However, we did not observe evidence of transdifferentiation or cell fusion of BM-derived cells. The beneficial effects of G-CSF were dependent on the integrity of BM. In conclusion, G-CSF produced a therapeutic effect in a rodent model of DN, which was attributed, at least in part, to the actions of BM-derived cells. (C) 2015 Elsevier Ireland Ltd. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by a Medical Research Center grant (2011-0028261) funded by the National Research Foundation of Korea (NRF) of the Korea government (MSIP); a California Institute for Regenerative Medicine (CIRM) Comprehensive Research Grant [RC1-00125-1]; NIH Grants. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER IRELAND LTD | en_US |
dc.subject | Diabetic neuropathy | en_US |
dc.subject | Granulocyte-colony stimulating factor | en_US |
dc.subject | Bone marrow-derived cells | en_US |
dc.title | Granulocyte-colony stimulating factor as a treatment for diabetic neuropathy in rat | en_US |
dc.type | Article | en_US |
dc.relation.volume | 414 | - |
dc.identifier.doi | 10.1016/j.mce.2015.07.014 | - |
dc.relation.page | 64-72 | - |
dc.relation.journal | MOLECULAR AND CELLULAR ENDOCRINOLOGY | - |
dc.contributor.googleauthor | Kim, Kyung-Soo | - |
dc.contributor.googleauthor | Song, Yi-Sun | - |
dc.contributor.googleauthor | Jin, Jiyong | - |
dc.contributor.googleauthor | Joe, Jun-Ho | - |
dc.contributor.googleauthor | So, Byung-Im | - |
dc.contributor.googleauthor | Park, Jun-Young | - |
dc.contributor.googleauthor | Fang, Cheng-Hu | - |
dc.contributor.googleauthor | Kim, Mi Jung | - |
dc.contributor.googleauthor | Cho, Youl-Hee | - |
dc.contributor.googleauthor | Ro, Young-Suck | - |
dc.relation.code | 2015002239 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | romio | - |
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