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dc.contributor.author신정훈-
dc.date.accessioned2017-08-03T01:14:43Z-
dc.date.available2017-08-03T01:14:43Z-
dc.date.issued2015-10-
dc.identifier.citationCELL TRANSPLANTATION, v. 24, NO 10, Page. 2055-2064en_US
dc.identifier.issn0963-6897-
dc.identifier.issn1555-3892-
dc.identifier.urihttp://journals.sagepub.com/doi/10.3727/096368914X685609-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/28232-
dc.description.abstractHuman amniotic epithelial cells (h-ABCs) have been shown to differentiate into cardiomyocyte-like cells in vivo that can regenerate myocardial tissue and improve cardiac function in a rat model of myocardial infarction (MI). In this study, we investigated the paracrine factors released from h-AECs under hypoxic conditions to elucidate the possible mechanisms underlying this previously reported phenomenon of h-AEC-mediated cardiac repair. We used hypoxic cell culture conditions to simulate myocardial infarction in vitro. In comparison to normal conditions, we found that h-ABCs secreted higher levels of several cytokines, including angiogenin (ANG), epidermal growth factor (EGF), interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1. To determine whether transplanted h-ABCs express these proangiogenic cytokines in vivo, we ligated the coronary artery of rats to cause MI and injected either h-ABCs or saline into the infarcted area. We found that the infarct and border zones of rat myocardium treated with h-AECs had higher expression levels of the human-origin cytokines ANG, EGF, IL-6, and MCP-1 compared to the tissues of saline-treated rats. In conclusion, h-ABCs secreted proangiogenic cytokines in a rat model of MI, which may suggest that the paracrine effect by h-ABCs could regenerate myocardial tissue and improve cardiac function.en_US
dc.description.sponsorshipThis work was supported by the research fund of Hanyang University HY-2013. The authors declare no conflicts of interest.en_US
dc.language.isoenen_US
dc.publisherCOGNIZANT COMMUNICATION CORPen_US
dc.subjectAmniotic epithelial cellsen_US
dc.subjectMyocardial infarction (MI)en_US
dc.subjectParacrineen_US
dc.subjectCytokineen_US
dc.titleTransplanted Human Amniotic Epithelial Cells Secrete Paracrine Proangiogenic Cytokines in Rat Model of Myocardial Infarctionen_US
dc.typeArticleen_US
dc.relation.no10-
dc.relation.volume24-
dc.identifier.doi10.3727/096368914X685609-
dc.relation.page2055-2064-
dc.relation.journalCELL TRANSPLANTATION-
dc.contributor.googleauthorSong, Yi-Sun-
dc.contributor.googleauthorJoo, Hyun-Woo-
dc.contributor.googleauthorPark, In-Hwa-
dc.contributor.googleauthorShen, Guang-Yin-
dc.contributor.googleauthorLee, Yonggu-
dc.contributor.googleauthorShin, Jeong Hun-
dc.contributor.googleauthorKim, Hyuck-
dc.contributor.googleauthorShin, Il-Seob-
dc.contributor.googleauthorKim, Kyung-Soo-
dc.relation.code2015001645-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidhyapex-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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