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Beneficial effects of low dose radiation in response to the oncogenic KRAS induced cellular transformation

Title
Beneficial effects of low dose radiation in response to the oncogenic KRAS induced cellular transformation
Author
이수재
Keywords
CANCER; IRRADIATION; HYPERSENSITIVITY; PROLIFERATION; RADIOTHERAPY; INDUCTION; IMMUNITY; HORMESIS; THERAPY; REPAIR
Issue Date
2015-10
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v. 5, Page. 1-10
Abstract
Recently low dose irradiation has gained attention in the field of radiotherapy. For lack of understanding of the molecular consequences of low dose irradiation, there is much doubt concerning its risks on human beings. In this article, we report that low dose irradiation is capable of blocking the oncogenic KRAS-induced malignant transformation. To address this hypothesis, we showed that low dose irradiation, at doses of 0.1 Gray (Gy); predominantly provide defensive response against oncogenic KRAS - induced malignant transformation in human cells through the induction of antioxidants without causing cell death and acts as a critical regulator for the attenuation of reactive oxygen species (ROS). Importantly, we elucidated that knockdown of antioxidants significantly enhanced ROS generation, invasive and migratory properties and abnormal acini formation in KRAS transformed normal as well as cancer cells. Taken together, this study demonstrates that low dose irradiation reduces the KRAS induced malignant cellular transformation through diminution of ROS. This interesting phenomenon illuminates the beneficial effects of low dose irradiation, suggesting one of contributory mechanisms for reducing the oncogene induced carcinogenesis that intensify the potential use of low dose irradiation as a standard regimen.
URI
http://www.nature.com/articles/srep15809http://hdl.handle.net/20.500.11754/27964
ISSN
2045-2322
DOI
10.1038/srep15809
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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