Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤채옥 | - |
dc.date.accessioned | 2017-06-13T02:47:20Z | - |
dc.date.available | 2017-06-13T02:47:20Z | - |
dc.date.issued | 2015-09 | - |
dc.identifier.citation | COLLOIDS AND SURFACES B-BIOINTERFACES, v. 133, Page. 254-262 | en_US |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.issn | 1873-4367 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0927776515003914 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/27767 | - |
dc.description.abstract | In this study, we report the development of a novel, redox-sensitive chitosan-based targeted drug delivery system, containing two drugs. We determined whether the synthesized polymeric micelles (HPTOC-DOX) were suitable as a drug carrier. The formation of HPTOC-DOX micelles was confirmed by H-1 NMR. HPTOC-DOX formed micelles of approximately 151.9 similar to 311.2 nm in size in aqueous solution. Analysis of the drug release profile of HPTOC-DOX in different pH conditions (pH 5.2, 6.2, and 7.4) indicated that DOX was released from HPTOC-DOX micelles at acidic pH (5.2 or 6.2), while almost no DOX was released at pH 7.4. In vitro cell cytotoxicity and hemolysis assays indicated that HPTOC-DOX micelles safely deliver anti-cancer drugs and decrease the cytotoxicity of DOX. In vitro anti-cancer activity assays, confocal laser scanning microscopy analysis of SK-BR-3 cells, and in vivo anti-tumor activity in SK-BR-3-derived tumor-bearing mice were used to evaluate synergistic drug effects and the effect of the targeting peptide (anti-human epidermal growth factor receptor 2 [HER2] target peptide, epitope form; LTVSPWY) on receptor-mediated endocytosis. (C) 2015 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Ministry of Science, ICT & Future Planning (NRF-2014R1A2A1A10053027). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | Chitosan | en_US |
dc.subject | Doxorubicin | en_US |
dc.subject | pH-sensitive | en_US |
dc.subject | Targeted delivery | en_US |
dc.title | Targeting delivery of tocopherol and doxorubicin grafted-chitosan polymeric micelles for cancer therapy: In vitro and in vivo evaluation | en_US |
dc.type | Article | en_US |
dc.relation.volume | 133 | - |
dc.identifier.doi | 10.1016/j.colsurfb.2015.06.018 | - |
dc.relation.page | 254-262 | - |
dc.relation.journal | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.contributor.googleauthor | Nam, Joung-Pyo | - |
dc.contributor.googleauthor | Lee, Kyeong-Jae | - |
dc.contributor.googleauthor | Choi, Joung-Woo | - |
dc.contributor.googleauthor | Yun, Chae-Ok | - |
dc.contributor.googleauthor | Nah, Jae-Woon | - |
dc.relation.code | 2015001660 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | chaeok | - |
dc.identifier.researcherID | P-3698-2015 | - |
dc.identifier.orcid | http://orcid.org/0000-0002-9466-4531 | - |
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