Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이종민 | - |
dc.date.accessioned | 2017-06-09T00:47:50Z | - |
dc.date.available | 2017-06-09T00:47:50Z | - |
dc.date.issued | 2015-09 | - |
dc.identifier.citation | Alzheimer's and Dementia, v. 1, NO 2, Page. 95-102 | en_US |
dc.identifier.issn | 2352-8737 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S2352873715000189 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/27703 | - |
dc.description.abstract | Introduction We conducted a phase 1 clinical trial in nine patients with mild-to-moderate Alzheimer's disease to evaluate the safety and dose-limiting toxicity of stereotactic brain injection of human umbilical cord blood–derived mesenchymal stem cells (hUCB-MSCs). Methods The low- (n = 3) and high-dose (n = 6) groups received a total of 3.0 × 106 cells/60 μL and 6.0 × 106 cells/60 μL, respectively, into the bilateral hippocampi and right precuneus. Results No patient showed serious adverse events including fever during the 24-month follow-up period. During the 12-week follow-up period, the most common acute adverse event was wound pain from the surgical procedure (n = 9), followed by headache (n = 4), dizziness (n = 3), and postoperative delirium (n = 3). There was no dose-limiting toxicity. Discussion Administration of hUCB-MSCs into the hippocampus and precuneus by stereotactic injection was feasible, safe, and well tolerated. Further trials are warranted to test the efficacy. | en_US |
dc.description.sponsorship | The authors thank Yoon Sun Yang and Wonil Oh from MEDIPOST Co, Ltd for providing human umbilical cord blood–derived mesenchymal stem cells. This study was supported by a grant of the Korean Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (HI12C1821). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | Mesenchymal stem cell | en_US |
dc.subject | Stereotactic injection | en_US |
dc.subject | Hippocampus | en_US |
dc.subject | Precuneus | en_US |
dc.title | Stereotactic brain injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer's disease dementia: A phase 1 clinical trial | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 1 | - |
dc.identifier.doi | 10.1016/j.trci.2015.06.007 | - |
dc.relation.page | 95-102 | - |
dc.relation.journal | Alzheimer's and Dementia | - |
dc.contributor.googleauthor | Kim, Hee Jin | - |
dc.contributor.googleauthor | Seo, Sang Won | - |
dc.contributor.googleauthor | Chang, Jong Wook | - |
dc.contributor.googleauthor | Lee, Jung Il | - |
dc.contributor.googleauthor | Kim, Chi Hun | - |
dc.contributor.googleauthor | Chin, Juhee | - |
dc.contributor.googleauthor | Choi, Soo Jin | - |
dc.contributor.googleauthor | Kwon, Hunki | - |
dc.contributor.googleauthor | Yun, Hyuk Jin | - |
dc.contributor.googleauthor | Lee, Jong Min | - |
dc.relation.code | 2015018207 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING | - |
dc.identifier.pid | ljm | - |
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