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dc.contributor.author배상철-
dc.date.accessioned2017-06-07T06:41:36Z-
dc.date.available2017-06-07T06:41:36Z-
dc.date.issued2015-09-
dc.identifier.citationCLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v. 33, NO 5, Page. 647-654en_US
dc.identifier.issn0392-856X-
dc.identifier.urihttp://europepmc.org/abstract/med/26314337-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/27650-
dc.description.abstractObjective The aim of this study is to explore whether Fc gamma receptor (FCGR) polymorphisms are associated with the susceptibility to rheumatoid arthritis (RA). Methods We conducted a meta-analysis on the association between FCGR2A H131R (rs1801274), FCGR3A F158V (rs396991), and FCGR3B NA1INA2 polymorphisms and RA susceptibility Results A total of seventeen studies reported in fourteen articles (4,418 patients with RA and 3,560 controls) were considered in our meta-analysis. In all of the study subjects, meta-analysis indicated an association between RA and FCGR2A R allele (OR=0.877, 95% CI=0.792-0.971, p=0.011). Stratification by ethnicity indicated an association between FCGR2A R allele and RA in Europeans (OR=0.816, 95% CI=0.687-0.968, p=0.020), but not in East Asians (OR=0.900, 95% CI=0.778-1.040, p=0.154). Meta-analysis revealed an association between RA and FCGR3A VV vs. FF genotype in all the study subjects (OR=1.210, 95% CI=1.067-1.479, p=0.006). Stratification by ethnicity indicated an association between FCGR3A VV genotype and RA compared to FF genotype in Europeans (OR=1.350, 95% CI=1.107-1.646, p=0.003), but not in East Asians and South Asians. No association was observed between RA and FCGR3B polymorphisms on performing the meta-analysis. Conclusion Although no relationship was found between the FCGR3B polymorphism and RA susceptibility, FCGR2A and FCGR3A polymorphisms were found to be associated With RA in Europeans, but not in Asians.en_US
dc.description.sponsorshipthis study was supported in part by a grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI13C2124).en_US
dc.language.isoenen_US
dc.publisherCLINICAL & EXPER RHEUMATOLOGYen_US
dc.subjectFCG receptoren_US
dc.subjectpolymorphismen_US
dc.subjectrheumatoid arthritisen_US
dc.subjectmeta-analysisen_US
dc.titleFCGR2A, FCGR3A, FCGR3B polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysisen_US
dc.typeArticleen_US
dc.relation.no5-
dc.relation.volume33-
dc.relation.page647-654-
dc.relation.journalCLINICAL AND EXPERIMENTAL RHEUMATOLOGY-
dc.contributor.googleauthorLee, Y. H.-
dc.contributor.googleauthorBae, S.-C.-
dc.contributor.googleauthorSong, G. G.-
dc.relation.code2015001627-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidscbae-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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