Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2017-06-07T06:41:36Z | - |
dc.date.available | 2017-06-07T06:41:36Z | - |
dc.date.issued | 2015-09 | - |
dc.identifier.citation | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v. 33, NO 5, Page. 647-654 | en_US |
dc.identifier.issn | 0392-856X | - |
dc.identifier.uri | http://europepmc.org/abstract/med/26314337 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/27650 | - |
dc.description.abstract | Objective The aim of this study is to explore whether Fc gamma receptor (FCGR) polymorphisms are associated with the susceptibility to rheumatoid arthritis (RA). Methods We conducted a meta-analysis on the association between FCGR2A H131R (rs1801274), FCGR3A F158V (rs396991), and FCGR3B NA1INA2 polymorphisms and RA susceptibility Results A total of seventeen studies reported in fourteen articles (4,418 patients with RA and 3,560 controls) were considered in our meta-analysis. In all of the study subjects, meta-analysis indicated an association between RA and FCGR2A R allele (OR=0.877, 95% CI=0.792-0.971, p=0.011). Stratification by ethnicity indicated an association between FCGR2A R allele and RA in Europeans (OR=0.816, 95% CI=0.687-0.968, p=0.020), but not in East Asians (OR=0.900, 95% CI=0.778-1.040, p=0.154). Meta-analysis revealed an association between RA and FCGR3A VV vs. FF genotype in all the study subjects (OR=1.210, 95% CI=1.067-1.479, p=0.006). Stratification by ethnicity indicated an association between FCGR3A VV genotype and RA compared to FF genotype in Europeans (OR=1.350, 95% CI=1.107-1.646, p=0.003), but not in East Asians and South Asians. No association was observed between RA and FCGR3B polymorphisms on performing the meta-analysis. Conclusion Although no relationship was found between the FCGR3B polymorphism and RA susceptibility, FCGR2A and FCGR3A polymorphisms were found to be associated With RA in Europeans, but not in Asians. | en_US |
dc.description.sponsorship | this study was supported in part by a grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI13C2124). | en_US |
dc.language.iso | en | en_US |
dc.publisher | CLINICAL & EXPER RHEUMATOLOGY | en_US |
dc.subject | FCG receptor | en_US |
dc.subject | polymorphism | en_US |
dc.subject | rheumatoid arthritis | en_US |
dc.subject | meta-analysis | en_US |
dc.title | FCGR2A, FCGR3A, FCGR3B polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 33 | - |
dc.relation.page | 647-654 | - |
dc.relation.journal | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | - |
dc.contributor.googleauthor | Lee, Y. H. | - |
dc.contributor.googleauthor | Bae, S.-C. | - |
dc.contributor.googleauthor | Song, G. G. | - |
dc.relation.code | 2015001627 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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