245 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author배상철-
dc.date.accessioned2017-06-07T06:36:27Z-
dc.date.available2017-06-07T06:36:27Z-
dc.date.issued2015-09-
dc.identifier.citationZEITSCHRIFT FUR RHEUMATOLOGIE, v. 74, NO 7, Page. 637-645en_US
dc.identifier.issn0340-1855-
dc.identifier.issn1435-1250-
dc.identifier.urihttps://link.springer.com/article/10.1007/s00393-014-1493-x-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/27649-
dc.description.abstractThe aim of this study was to explore whether polymorphisms in miR-146a, miR-499 and IRAK1 are associated with susceptibility to inflammatory arthritis. Manual searches performed in the MEDLINE and EMBASE databases were used to identify published articles in which the roles of microRNA (miRNA) and IRAK1 polymorphisms in inflammatory arthritis were determined. A meta-analysis was conducted to investigate associations of the miR-146a rs2910164, miR-499 rs3746444, IRAK1 rs3027898 and IRAK1 rs1059703 polymorphisms with susceptibility to inflammatory arthritis. Nine studies containing 1224 patients and 1841 controls were included in the meta-analysis. The meta-analysis revealed no association between inflammatory arthritis and the rs2910164 C allele of miR-146a (odds ratio, OR = 0.974; 95 % confidence interval, CI = 0.810-1.091; p = 0.650). Stratification by ethnicity or disease type revealed no association between the miR-146a C allele and inflammatory arthritis in European, Middle Eastern or Asian patients with rheumatoid arthritis (RA) or juvenile idiopathic arthritis (JIA). However, the meta-analysis revealed an overall association between RA and the miR-499 rs374644 C (OR = 1.123, 95 % CI = 1.019-2.586, p = 0.041); stratification by ethnicity revealed a particular association in Middle Eastern populations (OR = 1.943, 95 % CI = 1.508-2.504, p = 2.7 x 10(-8)). The meta-analysis of IRAK1 polymorphisms revealed an association between inflammatory arthritis and the rs3027898 CC genotype (OR = 2.602, 95 % CI = 1.387-4.879, p = 0.003). An analysis using the homozygote contrast showed the same pattern for the rs3027898 CC genotype (OR = 2.472, 95 % CI = 1.300-4.700, p = 0.006). No association between inflammatory arthritis and the rs1059703 polymorphism was found. This meta-analysis suggests that the miR-499 rs374644 and IRAKI rs3027898 polymorphisms are associated with susceptibility to inflammatory arthritis.en_US
dc.description.sponsorshipThis study was supported in part by a grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI13C2124).en_US
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.subjectRheumatoid arthritisen_US
dc.subjectMicroRNAen_US
dc.subjectMEDLINEen_US
dc.subjectEthnicityen_US
dc.subjectGenotypeen_US
dc.titleThe association between susceptibility to inflammatory arthritis and miR-146a, miR-499 and IRAK1 polymorphisms A meta-analysisen_US
dc.typeArticleen_US
dc.relation.no7-
dc.relation.volume74-
dc.identifier.doi10.1007/s00393-014-1493-x-
dc.relation.page637-645-
dc.relation.journalZEITSCHRIFT FUR RHEUMATOLOGIE-
dc.contributor.googleauthorSong, G. G.-
dc.contributor.googleauthorBae, S.-C.-
dc.contributor.googleauthorSeo, Y. H.-
dc.contributor.googleauthorKim, J.-H.-
dc.contributor.googleauthorChoi, S. J.-
dc.contributor.googleauthorJi, J. D.-
dc.contributor.googleauthorLee, Y. H.-
dc.relation.code2015001130-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidscbae-
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE