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The role of steroid sulfatase as a prognostic factor in patients with endometrial cancer.

Title
The role of steroid sulfatase as a prognostic factor in patients with endometrial cancer.
Author
이원무
Keywords
Steroid sulfatase; endometrial cancer; prognostic factor
Issue Date
2015-09
Publisher
YONSEI UNIV COLL MEDICINE
Citation
YONSEI MEDICAL JOURNAL, v. 57(3), page 754-760
Abstract
Purpose: The aim of the study was to determine steroid sulfatase (STS) expression in endometrial cancer patients and its correlation with disease prognosis. Materials and Methods: We conducted a retrospective study in 59 patients who underwent surgery with histologically confirmed endometrial cancer from January 2000 to December 2011 at Hanyang University Hospital. Immuno-histochemical staining of STS was performed using rabbit polyclonal anti-STS antibody. Results: Sixteen of the 59 patients (27.1%) were positive for STS expression. Disease free survival (DFS) was 129.83 +/- 8.67 [95% confidence interval (CI): 112.84-146.82] months in the STS positive group (group A) and 111.06 +/- 7.17 (95% CI: 97.01-125.10) months in the STS negative group (group B) (p=0.92). Overall survival (OS) was 129.01 +/- 9.38 (95% CI: 110.63-147.38) months and 111.16 +/- 7.10 (95% CI: 97.24-125.07) months for the groups A and B, respectively (p=0.45). Univariate analysis revealed that FIGO stage and adjuvant therapy are significantly associated with DFS and OS. However, in multivariate analysis, FIGO stage and adjuvant therapy did not show any statistical significance with DFS and OS. STS was also not significantly associated with DFS and OS in univariate and multivariate analysis. Conclusion: STS expression was not significantly associated with DFS and OS, despite positive STS expression in 27% of endometrial cancer patients. Therefore, the role of STS as a prognostic factor in patients with endometrial cancer remains unclear and requires further research.
URI
https://synapse.koreamed.org/search.php?where=aview&id=10.3349/ymj.2016.57.3.754&code=0069YMJ&vmode=FULLhttp://hdl.handle.net/20.500.11754/27596
ISSN
0513-5796; 1976-2437
DOI
10.3349/ymj.2016.57.3.754
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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