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SHEARWAVE ELASTOGRAPHY FOR ASSESSMENT OF STEATOHEPATITIS AND HEPATIC FIBROSIS IN RAT MODELS OF NON-ALCOHOLIC FATTY LIVER DISEASE

Title
SHEARWAVE ELASTOGRAPHY FOR ASSESSMENT OF STEATOHEPATITIS AND HEPATIC FIBROSIS IN RAT MODELS OF NON-ALCOHOLIC FATTY LIVER DISEASE
Author
장기석
Keywords
Shear wave elastography; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Liver elasticity; Hepatic fibrosis
Issue Date
2015-09
Publisher
ELSEVIER SCIENCE INC
Citation
ULTRASOUND IN MEDICINE AND BIOLOGY, v. 41, NO 12, Page. 3205-3215
Abstract
The purpose of this study was to evaluate shear wave elastography (SWE) as a method for determining the severity of non-alcoholic fatty liver disease (NAFLD) and the stage of hepatic fibrosis, as well as the major determinants of liver elasticity among the various histologic and biomolecular changes associated with NAFLD. Rat NAFLD models with various degrees of NAFLD severity were created and imaged using SWE. The explanted livers were subjected to histopathologic evaluation and RNA expression analysis. Among the histologic and biomolecular findings, the fibrosis stage and the collagen RNA level were significant independent factors associated with liver elasticity (p ˂ 0.001). Liver elasticity was effective in detecting non-alcoholic steatohepatitis (NASH) and in determining fibrosis stage, and the corresponding areas under the receiver operating characteristic curves were 0.963 and 0.927-0.997, respectively. In conclusion, SWE is a potential non-invasive method for the detection of NASH and staging of hepatic fibrosis in patients with NAFLD. (C) 2015 World Federation for Ultrasound in Medicine Biology.
URI
http://www.sciencedirect.com/science/article/pii/S0301562915004718http://hdl.handle.net/20.500.11754/27588
ISSN
0301-5629; 1879-291X
DOI
10.1016/j.ultrasmedbio.2015.07.025
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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