329 0

Materials from Mussel-Inspired Chemistry for Cell and Tissue Engineering Applications

Title
Materials from Mussel-Inspired Chemistry for Cell and Tissue Engineering Applications
Author
신흥수
Keywords
POTENTIAL BIOMEDICAL APPLICATIONS; MEDIATED SURFACE MODIFICATION; SELF-ASSEMBLED MONOLAYERS; ENDOTHELIAL GROWTH-FACTOR; GUIDED BONE REGENERATION; MESENCHYMAL STEM-CELLS; GLY-ASP PEPTIDES; IN-VITRO; ELECTROSPUN FIBERS; OSTEOGENIC DIFFERENTIATION
Issue Date
2015-09
Publisher
AMER CHEMICAL SOC
Citation
BIOMACROMOLECULES, v. 16, NO 9, Page. 2541-2555
Abstract
Current advances in biomaterial fabrication techniques have broadened their application in different realms of biomedical engineering, spanning from drug delivery to tissue engineering. The success of biomaterials depends highly on the ability to modulate cell and tissue responses, including cell adhesion, as well as induction of repair and immune processes. Thus, most recent approaches in the field have concentrated on functionalizing biomaterials with different biomolecules intended to evoke cell- and tissue-specific reactions. Marine mussels produce mussel adhesive proteins (MAPs), which help them strongly attach to different surfaces, even under wet conditions in the ocean. Inspired by mussel adhesiveness, scientists discovered that dopamine undergoes self-polymerization at alkaline conditions. This reaction provides a universal coating for metals, polymers, and ceramics, regardless of their chemical and physical properties. Furthermore, this polymerized layer is enriched with catechol groups that enable immobilization of primary amine or thiol-based biomolecules via a simple dipping process. Herein, this review explores the versatile surface modification techniques that have recently been exploited in tissue engineering and summarizes polydopamine polymerization mechanisms, coating process parameters, and effects on substrate properties. A brief discussion of polydopamine-based reactions in the context of engineering various tissue types, including bone, blood vessels, cartilage, nerves, and muscle, is also provided.
URI
http://pubs.acs.org/doi/abs/10.1021/acs.biomac.5b00852http://hdl.handle.net/20.500.11754/27520
ISSN
1525-7797; 1526-4602
DOI
10.1021/acs.biomac.5b00852
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE