190 0

Secretion rates of human nasal submucosal glands from patients with chronic rhinosinusitis or cystic fibrosis

Title
Secretion rates of human nasal submucosal glands from patients with chronic rhinosinusitis or cystic fibrosis
Author
정진혁
Keywords
Fluid secretion; carbachol; chronic rhinosinusitis; cystic fibrosis; forskolin; nasal polyp; submucosal gland
Issue Date
2015-09
Publisher
OCEAN SIDE PUBLICATIONS INC
Citation
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, v. 29, NO 5, Page. 334-338
Abstract
Background: A majority of patients with cystic fibrosis (CF) have chronic rhinosinusitis (CRS) and/or nasal polyps, both of which may be secondary to reduced fluid secretion from nasal submucosal glands. Objective: To determine whether decreased fluid secretion from nasal submucosal glands also occurs in patients without CF and with CRS. Methods: Inferior turbinates of the nasal cavity were harvested from controls, subjects with CRS, and subjects with CF (n = 5‐7 per group). The secretion rates of the nasal submucosal glands of the three groups in response to carbachol and forskolin were measured by using time lapse digital imaging of mucus bubbles from single glands as they formed on the mucosal surface under oil. Results: Carbachol-stimulated secretion rates were the following: controls, 1670 ± 381 pl·min−1·gland−1; CRS, 965 ± 440 pl·min−1·gland−1; and CF, 933 ± 588 pl·min−1·gland−1 (p = 0.23, Kruskal-Wallis test). Forskolin-stimulated secretion rates were the following: controls, 229 ± 14 pl·min−1·gland−1; CRS, 154 ± 48 pl·min−1·gland−1; and CF, 22 ± 15 pl·min−1·gland−1 (p = 0.008, Kruskal-Wallis test). The ratio of the average secretion rate induced by forskolin to that induced by carbachol was 13.7% in the controls, and 15.9% in CRS and 2.3% in CF groups. Conclusion: The only significant difference in this small study was decreased forskolin-stimulated secretion in subjects with CF relative to the other subjects. However, there was a trend toward reduced carbachol-stimulated secretion rates in subjects with CRS and with and without CF relative to controls. Additional studies are needed to determine if nasal submucosal gland hyposecretion occurs in CRS either as a contributor to or as a consequence of CRS pathogenesis.
URI
http://www.ingentaconnect.com/content/ocean/ajra/2015/00000029/00000005/art00011http://hdl.handle.net/20.500.11754/27509
ISSN
1945-8924; 1945-8932
DOI
10.2500/ajra.2015.29.4213
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE