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dc.contributor.author조은철-
dc.date.accessioned2017-05-29T01:38:58Z-
dc.date.available2017-05-29T01:38:58Z-
dc.date.issued2015-09-
dc.identifier.citationACS APPLIED MATERIALS & INTERFACES, v. 7, NO 36, Page. 20438-20446en_US
dc.identifier.issn1944-8244-
dc.identifier.urihttp://pubs.acs.org/doi/abs/10.1021/acsami.5b06413-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/27489-
dc.description.abstractWe present a simple and industrially accessible method of producing liquid crystalline lipid nanoparticles with various internal structures based on phytantriol, Pluronic F127, and vitamin E acetate. Bilayer vesicles were produced when an ethanolic solution dissolving the lipid components was mixed with deionized water. After the evaporation of ethanol from the aqueous mixture, vesicles were transformed into lipid-filled liquid crystalline nanoparticles with well-defined internal structures such as hexagonal lattices (mostly inverted cubic Pn3m), lined or coiled pattern (inverted hexagonal H-2), and disordered structure (inverse microemulsion, L-2), depending on the compositions. Further studies suggested that their internal structures were also affected by temperature. The internal structures were characterized from cryo-TEM and small-angle X-ray scattering results. Microcalorimetry studies were performed to investigate the degree of molecular ordering/crystallinity of lipid components within the nanostructures. From the comparative studies, we demonstrated the present method could produce the lipid nanoparticles with similar characteristics to those made from a conventional method. More importantly, the production only requires simple tools for mixing and ethanol evaporation and it is possible to produce 10 kg or so per batch of aqueous lipid nanopartides dispersions, enabling the large-scale production of the liquid crystalline nanopartides for various biomedical applications.en_US
dc.description.sponsorshipWe thank Amorepacific Corporation R&D Center for technical supports of this work. S.L., J.E.S., and E.C.C. are financially supported for this work by NRF (NRF-2012R1A1A1004697 and NRF-2015R1A2A2A01007003), the KETEP grant funded by the Ministry of Trade, Industry, and Energy of the Korean government (20133030000300), and National Coordinating Center for Global Cosmetics R&D (HN14C0083), South Korea.en_US
dc.language.isoenen_US
dc.publisherAMER CHEMICAL SOCen_US
dc.subjectevaporation methoden_US
dc.subjectlipid crystalline lipid nanoparticlesen_US
dc.subjectlarge scale synthesisen_US
dc.subjectvesicles to lipid-filled nanoparticle transitionsen_US
dc.subjectinternal structuresen_US
dc.titleA Simple Evaporation Method for Large-Scale Production of Liquid Crystalline Lipid Nanoparticles with Various Internal Structuresen_US
dc.typeArticleen_US
dc.relation.no36-
dc.relation.volume7-
dc.identifier.doi10.1021/acsami.5b06413-
dc.relation.page20438-20446-
dc.relation.journalACS APPLIED MATERIALS & INTERFACES-
dc.contributor.googleauthorKim, Do-Hoon-
dc.contributor.googleauthorLim, Sora-
dc.contributor.googleauthorShim, Jongwon-
dc.contributor.googleauthorSong, Ji Eun-
dc.contributor.googleauthorChang, Jong Soo-
dc.contributor.googleauthorJin, Kyeong Sik-
dc.contributor.googleauthorCho, Eun Chul-
dc.relation.code2015001547-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDEPARTMENT OF CHEMICAL ENGINEERING-
dc.identifier.pidenjoe-
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COLLEGE OF ENGINEERING[S](공과대학) > CHEMICAL ENGINEERING(화학공학과) > Articles
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