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대기 미세먼지가 천식 발생과 조절에 미치는 영향

Title
대기 미세먼지가 천식 발생과 조절에 미치는 영향
Other Titles
Effects of particulate matter in ambient air on the development and control of asthma
Author
김상헌
Keywords
Particulate matter; Asthma; Disease progression; Disease susceptibility
Issue Date
2015-09
Publisher
대한 소아알레르기 호흡기학회/대한천식알레르기학회
Citation
Allergy Asthma & Respiratory Disease, v. 3, NO 5, Page. 313-319
Abstract
There has been growing concern regarding the effects of ambient air pollution on asthma. Particulate matter (PM) is one of the major air pollutants affecting both general population and the patients with asthma. This paper reviews the recent evidence of the adverse effects of PM on the inception and morbidity of asthma. Epidemiological studies confirmed that short-term exposure to PM aggravated respiratory symptoms and lung function in asthma patients. Furthermore, PM induces acute exacerbations of asthma with increased risk of hospitalization and death. Long-term exposure to PM is responsible for new onset of asthma and lung function decline in both children and adults. Various mechanisms are involved in the effects of PM on airway including oxidative stress, augmentation of inflammation, promotion of allergen sensitization, induction of airway hyperresponsiveness, aggravation of rhinitis and DNA methylation. Special attention and care is needed for the patients with asthma to prevent the detrimental effects of PM. (Allergy Asthma Respir Dis 2015;3:313-319)
URI
https://synapse.koreamed.org/DOIx.php?id=10.4168/aard.2015.3.5.313http://hdl.handle.net/20.500.11754/27483
ISSN
2288-0402; 2288-0410
DOI
10.4168/aard.2015.3.5.313
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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